Duragesic and Cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Duragesic (fentanyl) and Cortef (hydrocortisone). Common drug interactions include vomiting among females and diverticulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Duragesic and Cortef. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Duragesic?

Duragesic has active ingredients of fentanyl. eHealthMe is studying from 66,597 Duragesic users. Check the latest studies of Duragesic.

What is Cortef?

Cortef has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 4,254 Cortef users. Check the latest studies of Cortef.

On Jul, 07, 2026

66 people who take Duragesic and Cortef together, and have interactions are studied.

What are the common drug interactions of Duragesic and Cortef, by gender? *:

female:

Vomiting
Bone disorder
Gingival infection (gum infection)
Osteonecrosis of jaw (death of bone of jaw)
Anaemia (lack of blood)
Tooth fracture
Bacteraemia (presence of bacteria in the blood)
Fatigue (feeling of tiredness)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Candidiasis (candidiasis or thrush is a fungal infection)

male:

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Blood lactate dehydrogenase increased
Confusional state
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Drug ineffective

What are the common drug interactions of Duragesic and Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Headache (pain in head)
Acne (skin problems that cause pimples)
Astrocytoma (tumour of the brain that originate in a particular kind of glial-cells)
Deafness
Deafness transitory (deafness temporary)
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Nausea (feeling of having an urge to vomit)

20-29:

n/a

30-39:

Ataxia (loss of full control of bodily movements)
Back pain
Cough
Decreased appetite
Depression
Drug ineffective
Gait disturbance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lung disorder (lung disease)
Mycobacterium avium complex infection

40-49:

Hyperkalaemia (damage to or disease of the kidney)
Migraine (headache)
Abscess (pus)
Anxiety
Aortic valve disease
Aortic valve incompetence
Back pain
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Breast cyst
Cardiac failure congestive

50-59:

Botulism (food poisoning caused by botulinum growing)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Contrast media allergy (reaction associated with the use of intravenous contrast material during radiology)
Depression
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea
Diplopia (double vision)
Drug hypersensitivity
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)

60+:

Diarrhoea
Anaemia (lack of blood)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pathological fracture (broken bone caused by disease)
Spinal osteoarthritis (joint cartilage loss in spine)
Tooth fracture
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bacteraemia (presence of bacteria in the blood)
Bone fragmentation
Breast cancer recurrent

What are the existing conditions these people have? *

Pain: 15 people, 22.73%
Nausea And Vomiting: 8 people, 12.12%
Nausea (feeling of having an urge to vomit): 8 people, 12.12%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 12.12%
Multiple Myeloma (cancer of the plasma cells): 8 people, 12.12%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 12.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 12.12%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.61%
Immunodeficiency Common Variable: 6 people, 9.09%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 6 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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