Dymista and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Dymista (azelastine hydrochloride; fluticasone propionate) and Zoloft (sertraline hydrochloride). Common drug interactions include petit mal epilepsy among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Dymista and Zoloft. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Dymista?

Dymista has active ingredients of azelastine hydrochloride; fluticasone propionate. It is often used in allergies. eHealthMe is studying from 4,407 Dymista users. Check the latest studies of Dymista.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 20, 2026

98 people who take Dymista and Zoloft together, and have interactions are studied.

What are the common drug interactions of Dymista and Zoloft, by gender? *:

female:

Petit mal epilepsy (absence seizure)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Pneumonia
Productive cough
Pruritus generalised (generalized itching)
Rib fracture
Stasis dermatitis (skin inflammation caused by blood pooling in the veins in your legs)
Stomatitis (inflammation of mucous membrane of mouth)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Swelling

male:

Pyrexia (fever)
Asthma
Rhinorrhoea (watery mucus discharge from the nose)
Smoke sensitivity
Urinary tract infection
Wheezing (a high-pitched whistling sound made while you breath)
Constipation
Malaise (a feeling of general discomfort or uneasiness)
Abdominal pain
Chest pain

What are the common drug interactions of Dymista and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fatigue (feeling of tiredness)
Headache (pain in head)
Pyrexia (fever)
Asthma
Blood pressure systolic decreased
Cough
Forced expiratory volume decreased (decreased lung expired air volume)
Hypersensitivity
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

20-29:

Therapeutic response unexpected
Throat tightness
Aphonia (inability to produce voice)
Arthralgia (joint pain)
Asthma
Blood pressure decreased
Blood urine present
Chest discomfort
Facial bones fracture (bone fracture of face)
Fungal infection

30-39:

Cough
Disease recurrence
Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)

40-49:

Pain
Urinary tract infection
Acne (skin problems that cause pimples)
Asthenia (weakness)
Asthma exercise induced
Drug ineffective
Procedural site reaction
Rash
Rosacea (a skin condition that causes facial redness)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

50-59:

n/a

60+:

Arthropathy
Rash
Drug abuse
Blood creatinine decreased
Blood magnesium decreased
Blood potassium decreased
Blood pressure decreased
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cataract (clouding of the lens inside the eye)
Decreased appetite

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 41 people, 41.84%
Insomnia (sleeplessness): 19 people, 19.39%
Hypersensitivity: 12 people, 12.24%
High Blood Pressure: 12 people, 12.24%
Asthma: 9 people, 9.18%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 7.14%
Stress And Anxiety: 6 people, 6.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 6.12%
High Blood Cholesterol: 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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