Econazole nitrate and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Econazole nitrate (econazole nitrate) and Methotrexate (methotrexate sodium). Common drug interactions include malaise among females and dysphagia among males.

The phase IV clinical study analyzes what interactions people have when they take Econazole nitrate and Methotrexate. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Econazole nitrate?

Econazole nitrate has active ingredients of econazole nitrate. It is often used in athlete's foot. eHealthMe is studying from 1,264 Econazole nitrate users. Check the latest studies of Econazole nitrate.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

36 people who take Econazole nitrate and Methotrexate together, and have interactions are studied.

Econazole nitrate and Methotrexate drug interactions.

What are the common drug interactions of Econazole Nitrate and Methotrexate, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Arthropathy
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Chest pain
Deafness
Disturbance in attention
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Fibromyalgia (a long-term condition which causes pain all over the body)
Furuncle (infection of the hair follicle)

male:

Dysphagia (a condition in which swallowing is difficult or painful)
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Injection site pruritus (severe itching at injection site)
Injection site reaction
Mass
Migraine (headache)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Oral candidiasis (fungal infection of mouth)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Econazole Nitrate and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Injection site haemorrhage (bleeding from injection site)

50-59:

Injection site mass
Injection site pain
Injection site rash
Injection site urticaria (rash of round, red welts on the skin at injection site)
Injection site warmth
Internal hernia (protrusion of an intraperitoneal viscous into a compartment or under a constricting band within the abdominal cavity)
Joint dislocation (a joint position is changed from normal position)
Localised infection (infection at the single location)
Pruritus (severe itching of the skin)
Rash

60+:

Rash
Anaemia (lack of blood)
Gamma-glutamyltransferase increased
Hyperkalaemia (damage to or disease of the kidney)
Memory impairment
Mouth ulceration (mouth ulcers)
Mucosal erosion (peeling off of mucous membrane)
Muscular weakness (muscle weakness)
Neutropenia (an abnormally low number of neutrophils)
Pain

What are the existing conditions these people have? *

Pain: 5 people, 13.89%
High Blood Cholesterol: 4 people, 11.11%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 8.33%
Pericardial Disease: 3 people, 8.33%
Seasonal Allergy (allergic condition due to certain season): 2 people, 5.56%
Pharyngeal Disorder: 2 people, 5.56%
Pemphigoid (tense blisters on the skin): 2 people, 5.56%
Joint Pain: 2 people, 5.56%
Fungal Skin Infection: 2 people, 5.56%
Erysipelas (bacterial skin infection): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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