Effexor xr and Suboxone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Effexor xr (venlafaxine hydrochloride) and Suboxone (buprenorphine hydrochloride; naloxone hydrochloride). Common drug interactions include abnormal behaviour among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Effexor xr and Suboxone. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Suboxone?

Suboxone has active ingredients of buprenorphine hydrochloride; naloxone hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 31,249 Suboxone users. Check the latest studies of Suboxone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

59 people who take Effexor xr and Suboxone together, and have interactions are studied.

Effexor xr and Suboxone drug interactions.

What are the common drug interactions of Effexor Xr and Suboxone, by gender? *:

female:

Abnormal behaviour
Abortion induced (medically referred abortion)
Abortion spontaneous (naturally occurring miscarriage)
Aggression
Alcohol intolerance
Alcohol use
Alcohol withdrawal syndrome
Alcoholism (problems with alcohol)
Anaemia (lack of blood)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)

male:

Pain
Suicide attempt
Asthenia (weakness)
Bipolar disorder (mood disorder)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Gastrointestinal motility disorder (abnormal intestinal contractions)
Haematochezia (passage of stools containing blood)
Hallucination (an experience involving the perception of something not present)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)

What are the common drug interactions of Effexor Xr and Suboxone, by age (0-1 to 60+)? *:

0-1:

Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Neonatal aspiration (aspiration by neonate)

2-9:

n/a

10-19:

n/a

20-29:

Pulmonary embolism (blockage of the main artery of the lung)
Malaise (a feeling of general discomfort or uneasiness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lactic acidosis (low ph in body tissues)
Mouth ulceration (mouth ulcers)
Drug ineffective
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Injury
Pain

30-39:

Abortion spontaneous (naturally occurring miscarriage)
Chest pain
Drug dependence
Gastroenteritis (inflammation of stomach and intestine)
Homicidal ideation (thoughts about human killing another human)
Loss of employment
Maternal exposure during pregnancy (use of substance during pregnancy)
Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Suicidal behaviour
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

40-49:

Abdominal discomfort
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood bilirubin increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Fall
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)

50-59:

Bipolar disorder (mood disorder)
Cardiac disorder
Dyspnoea (difficult or laboured respiration)
Fall
Hypoaesthesia (reduced sense of touch or sensation)
Suicidal ideation
Agitation (state of anxiety or nervous excitement)
Dysuria (painful or difficult urination)
Memory impairment
Oedema peripheral (superficial swelling)

60+:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Gait disturbance
Weight increased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Lactic acidosis (low ph in body tissues)
Malaise (a feeling of general discomfort or uneasiness)
Mouth ulceration (mouth ulcers)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)

What are the existing conditions these people have? *

Pain: 14 people, 23.73%
Drug Dependence: 12 people, 20.34%
Stress And Anxiety: 8 people, 13.56%
Nausea (feeling of having an urge to vomit): 8 people, 13.56%
Headache (pain in head): 8 people, 13.56%
Bipolar Disorder (mood disorder): 7 people, 11.86%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 6.78%
Nausea And Vomiting: 4 people, 6.78%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 6.78%
Joint Pain: 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor xr and Suboxone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously