Elavil and Fragmin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Fragmin (dalteparin sodium). Common drug interactions include anisocytosis among females and hypertension among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Fragmin. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Fragmin?

Fragmin has active ingredients of dalteparin sodium. It is often used in deep venous thrombosis. eHealthMe is studying from 11,999 Fragmin users. Check the latest studies of Fragmin.

On Aug, 10, 2026

27 people who take Elavil and Fragmin together, and have interactions are studied.

What are the common drug interactions of Elavil and Fragmin, by gender? *:

female:

Anisocytosis (patient's red blood cells are of unequal size)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Haematemesis (vomiting of blood)
Haematocrit decreased
Haemoglobin decreased
Hypertension (high blood pressure)

male:

Hypertension (high blood pressure)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Blood albumin decreased
Blood calcium decreased
Blood creatine phosphokinase increased
Bone disorder
Bone pain
Bunion (a painful swelling on the first joint of the big toe)
Cardiac disorder
Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Elavil and Fragmin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypertension (high blood pressure)
Abdominal distension
Abdominal pain
Abnormal behaviour
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Anogenital warts
Arrhythmia (irregular heartbeat)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Asthenia (weakness)

10-19:

n/a

20-29:

Blood culture positive
Chills (felling of cold)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pyrexia (fever)
Sepsis (a severe blood infection that can lead to organ failure and death)
Viral infection

30-39:

Abdominal pain upper
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Haematemesis (vomiting of blood)
Oesophageal ulcer haemorrhage (bleeding from oesophagus ulcer)
Photosensitivity reaction
Rash erythematous (redness of the skin)
Rash papular (redness with papule)
Vomiting

40-49:

Fall
Fistula (an abnormal connection or passageway between two)
Hip arthroplasty
Knee arthroplasty
Neoplasm malignant (cancer tumour)
Oral disorder (mouth disease)
Scar
Stem cell transplant
Cervicobrachial syndrome (pain in neck and arm with changing location)
Multiple fractures

50-59:

Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Chronic kidney disease
Adenocarcinoma of the cervix (cervical cancer)
Anisocytosis (patient's red blood cells are of unequal size)
Dysmenorrhoea (painful menstruation)
Haematocrit decreased
Haemoglobin decreased
Lymphocyte count decreased
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)
Monocyte percentage increased

60+:

Peptic ulcer perforation
Abdominal distension
Palpitations (feelings or sensations that your heart is pounding or racing)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Respiratory arrest (excl neonatal) (cessation of normal respiration due to failure of the lungs to function effectively (excluding neonatal))
Urinary tract infection
Duodenal ulcer perforation (untreated ulcer can burn through the wall of the stomach)
Fatigue (feeling of tiredness)
Febrile neutropenia (fever with reduced white blood cells)
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 14 people, 51.85%
Inflammation: 5 people, 18.52%
Nausea (feeling of having an urge to vomit): 3 people, 11.11%
High Blood Pressure: 3 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.11%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 2 people, 7.41%
Gastric Ulcer (stomach ulcer): 2 people, 7.41%
Gastric Disorder (disease of stomach): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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