Elavil and Nicotine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Nicotine (nicotine). Common drug interactions include abdominal pain among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Nicotine. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

On Jul, 16, 2026

49 people who take Elavil and Nicotine together, and have interactions are studied.

What are the common drug interactions of Elavil and Nicotine, by gender? *:

female:

Abdominal pain
Adjustment disorder
Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Back pain
Bipolar disorder (mood disorder)
Blood sodium decreased
Constipation
Disturbance in attention

male:

Drug dependence
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Asthenia (weakness)
Loss of consciousness
Neck pain
Sleep disorder
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Confusional state
Eye pain
Malaise (a feeling of general discomfort or uneasiness)

What are the common drug interactions of Elavil and Nicotine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abortion spontaneous (naturally occurring miscarriage)
Drug abuse
Maternal exposure during pregnancy (use of substance during pregnancy)
Asthenia (weakness)
Cardiac failure
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematocrit decreased
Haemoglobin decreased

30-39:

n/a

40-49:

Arthralgia (joint pain)
Drug toxicity
Erectile dysfunction
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Multiple drug overdose accidental
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nasopharyngeal disorder (disease of nasopharynx)
Accident at work
Disturbance in attention
Dizziness

50-59:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Suicidal ideation
Suicide attempt
Weight decreased
Adjustment disorder
Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Asthenia (weakness)
Bipolar disorder (mood disorder)

60+:

Memory impairment
Muscular weakness (muscle weakness)
Benign lung neoplasm (benign (non-cancerous) tumours of the lung)
Cachexia (loss of weight)
Chronic kidney disease
Constipation
Disease progression
Drug ineffective
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the existing conditions these people have? *

Pain: 14 people, 28.57%
High Blood Pressure: 6 people, 12.24%
Diabetes: 5 people, 10.20%
Constipation: 4 people, 8.16%
Insomnia (sleeplessness): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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