Eligard and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eligard (leuprolide acetate) and Protonix (pantoprazole sodium). Common drug interactions include osteonecrosis of jaw among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Eligard and Protonix. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Eligard?

Eligard has active ingredients of leuprolide acetate. It is often used in prostate cancer. eHealthMe is studying from 44,652 Eligard users. Check the latest studies of Eligard.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 18, 2026

60 people who take Eligard and Protonix together, and have interactions are studied.

What are the common drug interactions of Eligard and Protonix, by gender? *:

female:

Osteonecrosis of jaw (death of bone of jaw)
Pneumonia
Toothache (tooth pain)
Vomiting
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Confusional state
Cough
Deafness

male:

Anxiety
Muscular weakness (muscle weakness)
Prostatic specific antigen increased
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Oedema peripheral (superficial swelling)
Pain in extremity
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Injury

What are the common drug interactions of Eligard and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abscess (pus)
Activities of daily living impaired
Agitation (state of anxiety or nervous excitement)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arrhythmia (irregular heartbeat)
Arteriosclerosis (thickening and hardening of arteries)
Arthropathy
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain

40-49:

n/a

50-59:

Pneumonia
Abdominal pain upper
Cough
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)

60+:

Anxiety
Metastases to bone (cancer spreads to bone)
Nausea (feeling of having an urge to vomit)
Joint effusion (presence of extra fluid in joint covering)
Injury
Oedema peripheral (superficial swelling)
Pain in extremity
Prostatic specific antigen increased
Syncope (loss of consciousness with an inability to maintain postural tone)
Toothache (tooth pain)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 20 people, 33.33%
Sleep Disorder: 12 people, 20.00%
Toothaches (tooth pain): 7 people, 11.67%
Muscle Spasms (muscle contraction): 7 people, 11.67%
Depression: 5 people, 8.33%
Prostate Cancer Metastatic: 4 people, 6.67%
Bone Neoplasm Malignant (cancer of bone): 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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