Embolex and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Embolex (dihydroergotamine mesylate; heparin sodium; lidocaine hydrochloride) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include toxic epidermal necrolysis among females and hepatic enzyme increased among males.

The phase IV clinical study analyzes what interactions people have when they take Embolex and Cotrim. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Embolex?

Embolex has active ingredients of dihydroergotamine mesylate; heparin sodium; lidocaine hydrochloride. eHealthMe is studying from 1,161 Embolex users. Check the latest studies of Embolex.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

33 people who take Embolex and Cotrim together, and have interactions are studied.

What are the common drug interactions of Embolex and Cotrim, by gender? *:

female:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Diarrhoea
Dry skin
General physical health deterioration (weak health status)
Hypersensitivity
Leukopenia (less number of white blood cells in blood)
Oliguria (not enough urine)
Pruritus (severe itching of the skin)

male:

Hepatic enzyme increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Procedural headache
White blood cell count decreased
Blood bilirubin increased
Agitation (state of anxiety or nervous excitement)
Pyrexia (fever)
Acute myocardial infarction (acute heart attack)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Bladder neoplasm (bladder tumour)

What are the common drug interactions of Embolex and Cotrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)

40-49:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Rash erythematous (redness of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Stevens johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Coma (state of unconsciousness lasting more than six hours)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Encephalitis cytomegalovirus (inflammation of the brain due to cytomegalovirus)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)

50-59:

Hemiparesis (weakness on one side of the body)
Hypoaesthesia (reduced sense of touch or sensation)
Blood pressure increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hepatic steatosis (fatty liver disease)
Pseudomonas test positive
Urinary tract infection

60+:

Hepatic enzyme increased
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Procedural headache
White blood cell count decreased
Blood bilirubin increased
Agitation (state of anxiety or nervous excitement)
Pyrexia (fever)
Acute myocardial infarction (acute heart attack)
Bladder neoplasm (bladder tumour)
Intervertebral disc protrusion (spinal disc protrusion)

What are the existing conditions these people have? *

High Blood Pressure: 16 people, 48.48%
Sleep Disorder: 13 people, 39.39%
Diabetes: 12 people, 36.36%
Pain: 9 people, 27.27%
Multiple Myeloma (cancer of the plasma cells): 8 people, 24.24%
Type 2 Diabetes: 8 people, 24.24%
Back Pain: 7 people, 21.21%
Procedural Headache: 6 people, 18.18%
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans): 6 people, 18.18%
Urinary Tract Infection: 5 people, 15.15%

* Approximation only. Some reports may have incomplete information.

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