Enablex and Skelaxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enablex (darifenacin hydrobromide) and Skelaxin (metaxalone). Common drug interactions include hyperglycaemia among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Enablex and Skelaxin. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Skelaxin?

Skelaxin has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 9,706 Skelaxin users. Check the latest studies of Skelaxin.

On Jul, 19, 2026

25 people who take Enablex and Skelaxin together, and have interactions are studied.

What are the common drug interactions of Enablex and Skelaxin, by gender? *:

female:

Hyperglycaemia (high blood sugar)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Pneumonia
Psychomotor hyperactivity (feelings of extreme restlessness)
Sleep disorder
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Type 2 diabetes mellitus
Blood pressure increased

male:

Anaemia (lack of blood)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Back disorder
Hip arthroplasty
Memory impairment
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Enablex and Skelaxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Hyperglycaemia (high blood sugar)
Insomnia (sleeplessness)
Sleep disorder
Type 2 diabetes mellitus
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Vision blurred

40-49:

Cough
Injection site haemorrhage (bleeding from injection site)
Injection site nodule (small swelling or aggregation of cells in the body, esp. an abnormal one at injection site)
Nasal discomfort
Sinusitis (inflammation of sinus)
Throat irritation

50-59:

Cellulitis (infection under the skin)
Chest pain
Confusional state
Fatigue (feeling of tiredness)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Confusional state
Dry mouth
Headache (pain in head)
Hypertension (high blood pressure)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Nail disorder (disease of nail)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Oesophageal stenosis (narrowing of oesophagus)
Pneumonia

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 24.00%
Pain: 5 people, 20.00%
Depression: 5 people, 20.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 16.00%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 3 people, 12.00%
High Blood Cholesterol: 3 people, 12.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 12.00%
Abdominal Discomfort: 3 people, 12.00%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 8.00%
Muscle Tightness: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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