Enbrel and Sirolimus drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enbrel (etanercept) and Sirolimus (sirolimus). Common drug interactions include hepatic failure among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Enbrel and Sirolimus. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Sirolimus?

Sirolimus has active ingredients of sirolimus. eHealthMe is studying from 11,823 Sirolimus users. Check the latest studies of Sirolimus.

On Jul, 10, 2026

53 people who take Enbrel and Sirolimus together, and have interactions are studied.

What are the common drug interactions of Enbrel and Sirolimus, by gender? *:

female:

Hepatic failure (liver failure)
Septic shock (shock due to blood infection)
Staphylococcal infection (an infection with staphylococcus bacteria)
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Disease progression
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Staphylococcal bacteraemia (a bacterial infection of blood)
Dyspnoea (difficult or laboured respiration)
Adenovirus infection
Cytomegalovirus infection

male:

Abdominal pain
Diarrhoea haemorrhagic (bloody diarrhoea)
Enteritis (inflammation of the small intestine)
Febrile neutropenia (fever with reduced white blood cells)
Meningitis viral (viral inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Propionibacterium infection
Sepsis (a severe blood infection that can lead to organ failure and death)
Transplant failure (transplantation failed to meet outcome)
Nystagmus (a condition of involuntary eye movement)
Stem cell transplant

What are the common drug interactions of Enbrel and Sirolimus, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Petechiae (a small red or purple spot caused by bleeding into the skin)
Pyrexia (fever)
Rash
Rash macular (small, flat red spots)
Rash pruritic (redness with itching)
Surgery

10-19:

Adenovirus infection
Cytomegalovirus infection
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
Human herpesvirus 6 infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

20-29:

n/a

30-39:

Hepatic failure (liver failure)
Septic shock (shock due to blood infection)
Staphylococcal infection (an infection with staphylococcus bacteria)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Staphylococcal bacteraemia (a bacterial infection of blood)

40-49:

Abdominal pain
Diarrhoea haemorrhagic (bloody diarrhoea)
Diffuse large b-cell lymphoma (cancer of b cells, a type of white blood cell)
Diplopia (double vision)
Gait disturbance
Headache (pain in head)
Post transplant lymphoproliferative disorder
Vertigo
Weight decreased
Central nervous system lymphoma (cancer of central nervous system forms in lymph tissue)

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac flutter (abnormal heart rhythm)
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Oedema (fluid collection in tissue)

60+:

Anaemia (lack of blood)
Aphthous stomatitis (mouth ulcer)
Septic shock (shock due to blood infection)
Blepharitis (chronic inflammation of the eyelid)
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Gastroenteritis (inflammation of stomach and intestine)
Nasopharyngitis (inflammation of the nasopharynx)
Paraplegia (paralysis of the legs and lower body)
Renal disorder (kidney disease)

What are the existing conditions these people have? *

Immunodeficiency Disorders: 24 people, 45.28%
Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 12 people, 22.64%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 9.43%
Abdominal Pain: 5 people, 9.43%
Nausea (feeling of having an urge to vomit): 4 people, 7.55%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 4 people, 7.55%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 4 people, 7.55%
Stress And Anxiety: 3 people, 5.66%
Diarrhea: 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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