Endep and Topamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Endep (amitriptyline hydrochloride) and Topamax (topiramate). Common drug interactions include muscle spasms among females.

The phase IV clinical study analyzes what interactions people have when they take Endep and Topamax. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

On Jul, 28, 2026

15 people who take Endep and Topamax together, and have interactions are studied.

What are the common drug interactions of Endep and Topamax, by gender? *:

female:

Muscle spasms (muscle contraction)
Pain
Poor quality sleep
Stress
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Irritable bowel syndrome
Agitation (state of anxiety or nervous excitement)
Arthralgia (joint pain)
Asthenia (weakness)
Bradyphrenia (neurological term referring to the slowness of thought common to many disorders of the brain)

male:

n/a

What are the common drug interactions of Endep and Topamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Rash
Vaginal haemorrhage (vaginal bleeding)
Epistaxis (bleed from the nose)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Inflammation
Irritable bowel syndrome
Menstrual disorder (disease of menstrual cycle)
Overweight

30-39:

n/a

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Delusion (a false belief or opinion)
Hallucination (an experience involving the perception of something not present)

50-59:

Diarrhoea
Fall
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Nightmare (unpleasant dream)
Pain
Pain in extremity
Poor quality sleep
Stress

60+:

Delusion (a false belief or opinion)
Erythema (redness of the skin)
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Pruritus (severe itching of the skin)
Rash macular (small, flat red spots)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 33.33%
Quit Smoking: 4 people, 26.67%
Depression: 4 people, 26.67%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 6.67%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
Nausea (feeling of having an urge to vomit): 1 person, 6.67%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 6.67%
Irritable Bowel Syndrome: 1 person, 6.67%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Endep and Topamax?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously