Epclusa and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Flonase (fluticasone propionate). Common drug interactions include headache among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Flonase. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

43 people who take Epclusa and Flonase together, and have interactions are studied.

What are the common drug interactions of Epclusa and Flonase, by gender? *:

female:

Headache (pain in head)
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Eye pruritus (eye itching)
Fatigue (feeling of tiredness)
Gastric disorder (disease of stomach)
Insomnia (sleeplessness)
Muscle tightness
Panic attack
Pruritus (severe itching of the skin)

male:

Fatigue (feeling of tiredness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pain
Renal failure (kidney dysfunction)
Tooth loss
Abdominal pain upper
Arthralgia (joint pain)
Colonoscopy
Drug ineffective
Drug screen positive

What are the common drug interactions of Epclusa and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Colonoscopy
Drug screen positive
Fatigue (feeling of tiredness)
Maternal exposure during pregnancy (use of substance during pregnancy)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

40-49:

Blood glucose increased
Overdose

50-59:

Headache (pain in head)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Bone loss
Chronic kidney disease
Dysuria (painful or difficult urination)
Emotional distress
Fatigue (feeling of tiredness)
Nephrolithiasis (calculi in the kidneys)

60+:

Headache (pain in head)
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cardiac failure congestive
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Dehydration (dryness resulting from the removal of water)
Drug ineffective
Euphoric mood (excessively happy but may become angry or irritable)

What are the existing conditions these people have? *

Hepatitis C: 7 people, 16.28%

* Approximation only. Some reports may have incomplete information.

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