Epclusa and Pepcid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Pepcid (famotidine). Common drug interactions include fatigue among females and chronic obstructive pulmonary disease among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Pepcid. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Pepcid?

Pepcid has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 55,774 Pepcid users. Check the latest studies of Pepcid.

On Jul, 10, 2026

28 people who take Epclusa and Pepcid together, and have interactions are studied.

What are the common drug interactions of Epclusa and Pepcid, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Asthenia (weakness)
Constipation
Nausea (feeling of having an urge to vomit)
Anxiety
Dizziness
Dry mouth
Blood glucose increased
Overdose

male:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Gastric disorder (disease of stomach)
Diarrhoea
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Haemoglobin decreased
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Pain

What are the common drug interactions of Epclusa and Pepcid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood glucose increased
Overdose
Affect lability (emotional incontinence)
Blood pressure systolic increased
Conjunctivitis (pink eye)
Diplopia (double vision)
Dysuria (painful or difficult urination)
Insomnia (sleeplessness)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

Headache (pain in head)
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone density decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Constipation
Emotional distress
Gait disturbance

60+:

Anxiety
Diarrhoea
Confusional state
Constipation
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Haemoglobin decreased
Headache (pain in head)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Hepatitis C: 8 people, 28.57%
Hiv Infection: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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