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Ephedrine and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ephedrine (ephedra) and Codeine (codeine sulfate). Common drug interactions include anaemia among females and drug abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Ephedrine and Codeine. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Ephedrine?

Ephedrine has active ingredients of ephedra. It is often used in weight loss. eHealthMe is studying from 1,763 Ephedrine users. Check the latest studies of Ephedrine.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

On Jul, 15, 2026

22 people who take Ephedrine and Codeine together, and have interactions are studied.

Ephedrine and Codeine drug interactions.

What are the common drug interactions of Ephedrine and Codeine, by gender? *:

female:

  1. Anaemia (lack of blood)
  2. Anger
  3. Anxiety
  4. Aphthous ulcer (mouth ulcer)
  5. Arthralgia (joint pain)
  6. Asthenia (weakness)
  7. Breast disorder
  8. Breast mass
  9. Cardiac disorder
  10. Constipation

male:

  1. Drug abuse
  2. Drug hypersensitivity
  3. Overdose
  4. Road traffic accident

What are the common drug interactions of Ephedrine and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug abuse
  2. Overdose
  3. Road traffic accident

40-49:

n/a

50-59:

  1. Chronic kidney disease
  2. Diabetic nephropathy (diabetic kidney disease)
  3. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  4. Nephrogenic anaemia (anaemia due to kidney disease)
  5. Renal failure (kidney dysfunction)

60+:

  1. Loss of consciousness
  2. Malaise (a feeling of general discomfort or uneasiness)
  3. Asthenia (weakness)
  4. Breast disorder
  5. Breast mass
  6. Cardiac disorder
  7. Crying
  8. Depression
  9. Dizziness
  10. Dry mouth

What are the existing conditions these people have? *

  1. Anaesthesia: 5 people, 22.73%
  2. Insomnia (sleeplessness): 2 people, 9.09%
  3. Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Ephedrine and Codeine?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ephedrine and Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ephedrine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ephedrine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Codeine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ephedra and codeine sulfate (the active ingredients of Ephedrine and Codeine, respectively), and Ephedrine and Codeine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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