Epitol and Glucophage drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Epitol (carbamazepine) and Glucophage (metformin hydrochloride). Common drug interactions include urinary tract infection among females and balance disorder among males.
The phase IV clinical study analyzes what interactions people have when they take Epitol and Glucophage. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.
What is Epitol?
Epitol has active ingredients of carbamazepine. It is often used in bipolar disorder. eHealthMe is studying from 397 Epitol users. Check the latest studies of Epitol.
What is Glucophage?
Glucophage has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 60,851 Glucophage users. Check the latest studies of Glucophage.
18 people who take Epitol and Glucophage together, and have interactions are studied.

What are the common drug interactions of Epitol and Glucophage, by gender? *:
female:
- Urinary tract infection
- Memory impairment
- Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
- Strabismus (a disorder in which the two eyes do not line up in the same direction)
- Suicidal ideation
- Arthralgia (joint pain)
- Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
- Death
- Enuresis (repeated inability to control urination)
- Headache (pain in head)
male:
- Balance disorder
- Bladder cancer
- Speech disorder
- Dizziness
- Drug ineffective
- Facial neuralgia (pain of face)
- Facial pain
- Heart rate increased
- Mastication disorder (disease of chewing food)
- Palpitations (feelings or sensations that your heart is pounding or racing)
What are the common drug interactions of Epitol and Glucophage, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Urinary tract infection
- Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)
- Strabismus (a disorder in which the two eyes do not line up in the same direction)
- Suicidal ideation
- Enuresis (repeated inability to control urination)
- Headache (pain in head)
- Memory impairment
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Nausea (feeling of having an urge to vomit)
- Adjustment disorder with depressed mood
50-59:
- Death
60+:
- Balance disorder
- Bladder cancer
- Rash generalised (rash on most of body parts)
- Renal failure (kidney dysfunction)
- Speech disorder
- Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
- Chronic kidney disease
- Dizziness
- Drug ineffective
- Facial neuralgia (pain of face)
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 16 people, 88.89%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 33.33%
- Pain: 4 people, 22.22%
- Asthma: 3 people, 16.67%
- Hypersensitivity: 3 people, 16.67%
- Neuromyelitis Optica (inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis)): 2 people, 11.11%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 11.11%
- Hypervigilance: 1 person, 5.56%
- Depression: 1 person, 5.56%
- Drowsiness: 1 person, 5.56%
* Approximation only. Some reports may have incomplete information.
Do you take Epitol and Glucophage?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Epitol (397 reports)
- Glucophage (60,851 reports)
Browse all drug interactions of Epitol and Glucophage:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Epitol:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Glucophage:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Epitol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Glucophage and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Puvanendran R, Teo HZ, "Case report of use of Black Cohosh for carbamazepine induced hot flushes in a post menopausal woman", Maturitas, 2017 Jun .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Arshad F, Ladakhi Y, Khan MA, "A rare case of carbamazepine induced pancreatitis", International Journal of Students’ Research, 2013 Jul .
- Yava?o?lu I, Sarg?n G, Demirbulat A, "Carbamazepine and hematological malignancies", Turkish journal of haematology: official journal of Turkish Society of Haematology, 2013 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Puvanendran R, Teo HZ, "Case report of use of Black Cohosh for carbamazepine induced hot flushes in a post menopausal woman", Maturitas, 2017 Jun .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Arshad F, Ladakhi Y, Khan MA, "A rare case of carbamazepine induced pancreatitis", International Journal of Students’ Research, 2013 Jul .
- Yava?o?lu I, Sarg?n G, Demirbulat A, "Carbamazepine and hematological malignancies", Turkish journal of haematology: official journal of Turkish Society of Haematology, 2013 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on carbamazepine and metformin hydrochloride (the active ingredients of Epitol and Glucophage, respectively), and Epitol and Glucophage (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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