Epival and Prednisolone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epival (divalproex sodium) and Prednisolone (prednisolone). Common drug interactions include blood bilirubin increased among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Epival and Prednisolone. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Epival?

Epival has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 1,088 Epival users. Check the latest studies of Epival.

What is Prednisolone?

Prednisolone has active ingredients of prednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 212,675 Prednisolone users. Check the latest studies of Prednisolone.

On Jul, 19, 2026

24 people who take Epival and Prednisolone together, and have interactions are studied.

Epival and Prednisolone drug interactions.

What are the common drug interactions of Epival and Prednisolone, by gender? *:

female:

Blood bilirubin increased
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Cardiac murmur (an heart sound in valve abnormality)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic enzyme increased
Hepatotoxicity (chemical-driven liver damage)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Jaundice cholestatic

male:

Abdominal discomfort
Fatigue (feeling of tiredness)
Heart rate decreased
Mass
Cough
Ocular discomfort (a generic expression when there is lack of ease in/about the eyes)
Diarrhoea
Impaired healing
Lung neoplasm malignant (cancer tumour of lung)
Pain in jaw

What are the common drug interactions of Epival and Prednisolone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Infection
Lymphadenopathy (disease or enlargement of lymph nodes)
Nephropathy toxic (damage to kidney due to toxins)
Neutropenia (an abnormally low number of neutrophils)
Pain
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)

50-59:

Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hepatic enzyme increased
Hepatotoxicity (chemical-driven liver damage)
Hypomania (a mild form of mania, marked by elation and hyperactivity)
Jaundice cholestatic
Lung neoplasm (tumour of lung)

60+:

n/a

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 18 people, 75.00%
Uveitis (inflammation of the uvea): 8 people, 33.33%
Indigestion: 8 people, 33.33%
Psychotic Disorder: 2 people, 8.33%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 8.33%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 2 people, 8.33%
Hiv Infection: 2 people, 8.33%
Depression: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Epival and Prednisolone?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously