Zetonna and Epipen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zetonna (ciclesonide) and Epipen (epinephrine). Common drug interactions include chills among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Zetonna and Epipen. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Zetonna?

Zetonna has active ingredients of ciclesonide. eHealthMe is studying from 219 Zetonna users. Check the latest studies of Zetonna.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.



On Jul, 19, 2026

15 people who take Zetonna and Epipen together, and have interactions are studied.

Zetonna and Epipen drug interactions.

What are the common drug interactions of Zetonna and Epipen, by gender? *:

female:

  1. Chills (felling of cold)
  2. Cough
  3. Dyspnoea (difficult or laboured respiration)
  4. Erythema (redness of the skin)
  5. Eye swelling
  6. Headache (pain in head)
  7. Hypersensitivity
  8. Insomnia (sleeplessness)
  9. Malaise (a feeling of general discomfort or uneasiness)
  10. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)

male:

  1. Drug ineffective
  2. Upper respiratory tract infection

What are the common drug interactions of Zetonna and Epipen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Corneal abrasion (loss of the surface of cornea)
  2. Eye swelling
  3. Memory impairment
  4. Migraine with aura (headache with vision weakness)
  5. Presyncope
  6. Vision blurred
  7. Corneal disorder
  8. Dehydration (dryness resulting from the removal of water)
  9. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  10. Disorientation (disability in which the senses of time, direction, and recognition of people and places)

40-49:

n/a

50-59:

  1. Drug effect decreased

60+:

n/a

What are the existing conditions these people have? *

  1. Asthma: 5 people, 33.33%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 26.67%
  3. Immunodeficiency Common Variable: 3 people, 20.00%
  4. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 20.00%
  5. Hereditary Angioedema (recurrent episodes of severe swelling): 2 people, 13.33%
  6. Stress And Anxiety: 1 person, 6.67%
  7. Sleep Disorder: 1 person, 6.67%
  8. Pain: 1 person, 6.67%
  9. Nausea (feeling of having an urge to vomit): 1 person, 6.67%
  10. Multiple Allergies (allergy to multiple agents): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Zetonna and Epipen?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zetonna and Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zetonna:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zetonna and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epipen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ciclesonide and epinephrine (the active ingredients of Zetonna and Epipen, respectively), and Zetonna and Epipen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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