Eplerenone and Vitamin e drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eplerenone (eplerenone) and Vitamin e (tocopherols and tocotrienols). Common drug interactions include death among females and cardiac failure acute among males.

The phase IV clinical study analyzes what interactions people have when they take Eplerenone and Vitamin e. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

On Jul, 28, 2026

21 people who take Eplerenone and Vitamin e together, and have interactions are studied.

Eplerenone and Vitamin e drug interactions.

What are the common drug interactions of Eplerenone and Vitamin E, by gender? *:

female:

Death
Peripheral swelling
Arthropathy
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Constipation
Depression
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Insomnia (sleeplessness)
Pain

male:

Cardiac failure acute
Cardiac failure congestive
Hypotension (abnormally low blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Adverse drug reaction
Blood potassium decreased
Catheter site swelling
Chronic kidney disease
Depression
Device dislocation

What are the common drug interactions of Eplerenone and Vitamin E, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Catheter site swelling
Device dislocation

30-39:

n/a

40-49:

n/a

50-59:

Cardiac failure acute
Cardiac failure congestive
Hepatomegaly (abnormal enlargement of the liver)
Left ventricular failure (left ventricle fails to contract forcefully)
Nephrolithiasis (calculi in the kidneys)
Hypokalaemia (low potassium)
Blood potassium decreased
Transplant rejection (a transplant material is not worked)

60+:

Adverse event
Anaemia (lack of blood)
Insomnia (sleeplessness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Poor quality sleep
Rash erythematous (redness of the skin)
Rash pruritic (redness with itching)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 14.29%
Back Pain: 3 people, 14.29%
Pain: 2 people, 9.52%
Multiple Myeloma (cancer of the plasma cells): 2 people, 9.52%
Insomnia (sleeplessness): 2 people, 9.52%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 9.52%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%
Chest Pain: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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