Esidrix and Prograf drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esidrix (hydrochlorothiazide) and Prograf (tacrolimus). Common drug interactions include anorexia among females and electrocardiogram qt prolonged among males.

The phase IV clinical study analyzes what interactions people have when they take Esidrix and Prograf. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Esidrix?

Esidrix has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 1,846 Esidrix users. Check the latest studies of Esidrix.

What is Prograf?

Prograf has active ingredients of tacrolimus. It is often used in kidney transplant. eHealthMe is studying from 42,230 Prograf users. Check the latest studies of Prograf.

On Jul, 17, 2026

15 people who take Esidrix and Prograf together, and have interactions are studied.

What are the common drug interactions of Esidrix and Prograf, by gender? *:

female:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthenia (weakness)
Blood creatinine increased
Bradycardia (abnormally slow heart action)
Hepatic failure (liver failure)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

male:

Electrocardiogram qt prolonged
Hyperkalaemia (damage to or disease of the kidney)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Oedema (fluid collection in tissue)
Pleural effusion (water on the lungs)
Immunosuppressant drug level increased
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

What are the common drug interactions of Esidrix and Prograf, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Cerebral haemorrhage (bleeding within the brain)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

30-39:

n/a

40-49:

Drug ineffective
Drug resistance (reduction in effectiveness of a drug)
Cytomegalovirus colitis (an inflammation of the colon from virus)
Cytomegalovirus infection
Leukopenia (less number of white blood cells in blood)

50-59:

Hepatic failure (liver failure)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)
Colitis (inflammation of colon)
Multi-organ disorder (multiple organ disease)
Salmonellosis (an infection with salmonella bacteria)
Septic encephalopathy (disorder or disease of the brain due to blood infection with bacteria)
Confusional state
Encephalopathy (functioning of the brain is affected by some agent or condition)

60+:

Blood creatinine increased
Electrocardiogram qt prolonged
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Renal impairment (severely reduced kidney function)
Dyspnoea (difficult or laboured respiration)
Palpitations (feelings or sensations that your heart is pounding or racing)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure decreased

What are the existing conditions these people have? *

Immunodeficiency Disorders: 3 people, 20.00%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 2 people, 13.33%
Gout (uric acid crystals building up in the body): 2 people, 13.33%
Cytomegalovirus Infection: 2 people, 13.33%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 13.33%
Dehydration (dryness resulting from the removal of water): 2 people, 13.33%
Diabetes: 2 people, 13.33%
Fungal Infection: 2 people, 13.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 13.33%
Chronic Kidney Disease: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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