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Esidrix and Xeloda drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Esidrix (hydrochlorothiazide) and Xeloda (capecitabine). Common drug interactions include osteonecrosis among females and impaired healing among males.

The phase IV clinical study analyzes what interactions people have when they take Esidrix and Xeloda. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Esidrix?

Esidrix has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 1,846 Esidrix users. Check the latest studies of Esidrix.

What is Xeloda?

Xeloda has active ingredients of capecitabine. It is often used in colon cancer. eHealthMe is studying from 46,649 Xeloda users. Check the latest studies of Xeloda.

On Jul, 11, 2026

11 people who take Esidrix and Xeloda together, and have interactions are studied.

Esidrix and Xeloda drug interactions.

What are the common drug interactions of Esidrix and Xeloda, by gender? *:

female:

  1. Osteonecrosis (death of bone)
  2. Dehydration (dryness resulting from the removal of water)
  3. Renal failure acute (rapid kidney dysfunction)
  4. Vomiting
  5. Abdominal pain
  6. Diarrhoea

male:

  1. Impaired healing
  2. Wound infection
  3. Incisional hernia (hernia caused by an incompletely-healed surgical wound)
  4. Proteinuria (presence of protein in the urine)

What are the common drug interactions of Esidrix and Xeloda, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Dehydration (dryness resulting from the removal of water)
  2. Renal failure acute (rapid kidney dysfunction)
  3. Vomiting
  4. Impaired healing
  5. Wound infection

60+:

  1. Osteonecrosis (death of bone)
  2. Abdominal pain
  3. Dehydration (dryness resulting from the removal of water)
  4. Diarrhoea
  5. Incisional hernia (hernia caused by an incompletely-healed surgical wound)
  6. Proteinuria (presence of protein in the urine)
  7. Renal failure acute (rapid kidney dysfunction)
  8. Vomiting

What are the existing conditions these people have? *

  1. Rectal Cancer (cancer of rectum): 4 people, 36.36%
  2. High Blood Cholesterol: 2 people, 18.18%
  3. Pain: 1 person, 9.09%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 9.09%
  5. Gastric Cancer (stomach cancer): 1 person, 9.09%
  6. Diarrhea: 1 person, 9.09%
  7. Diabetes: 1 person, 9.09%
  8. Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 9.09%
  9. Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 1 person, 9.09%
  10. Breast Cancer Metastatic: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Esidrix and Xeloda?

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- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Esidrix and Xeloda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Esidrix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Xeloda:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Esidrix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xeloda and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide and capecitabine (the active ingredients of Esidrix and Xeloda, respectively), and Esidrix and Xeloda (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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