Estradiol and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Estradiol (estradiol) and Requip (ropinirole hydrochloride). Common drug interactions include fluid retention among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Estradiol and Requip. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Estradiol?

Estradiol has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 18,986 Estradiol users. Check the latest studies of Estradiol.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

On Jul, 29, 2026

55 people who take Estradiol and Requip together, and have interactions are studied.

What are the common drug interactions of Estradiol and Requip, by gender? *:

female:

Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)
Headache (pain in head)
Heart rate decreased
Hypoaesthesia (reduced sense of touch or sensation)
Joint swelling
Local swelling (swelling at the site of some application of substance or injury)
Loss of consciousness
Memory impairment

male:

Abdominal pain
Adverse drug reaction
Drug hypersensitivity
Dyspepsia (indigestion)
Feeling hot
Feeling of body temperature change
Heart rate decreased
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)

What are the common drug interactions of Estradiol and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Adverse drug reaction
Personality disorder
Psychotic disorder
Suicidal ideation
Suicide attempt

30-39:

Apnoea (suspension of external breathing)
Asthma
Sinus disorder (disease of sinus)
Snoring

40-49:

Renal vein thrombosis (blood clot in renal vein)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Chronic kidney disease
Abdominal discomfort
Anxiety
Asthma
Depression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)
Insomnia (sleeplessness)

50-59:

Drug ineffective
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest discomfort
Cough
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Abdominal discomfort
Arthralgia (joint pain)
Chronic kidney disease

60+:

Dizziness
Diarrhoea
Alopecia (absence of hair from areas of the body)
Anxiety
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Bacterial infection
Blood creatine increased
Blood glucose decreased

What are the existing conditions these people have? *

High Blood Pressure: 9 people, 16.36%
Depression: 8 people, 14.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 12.73%
Pain: 7 people, 12.73%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 12.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.73%
Headache (pain in head): 5 people, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 7.27%
High Blood Cholesterol: 3 people, 5.45%
Diarrhea: 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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