Excedrin and Metoclopramide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Excedrin (acetaminophen; aspirin; caffeine) and Metoclopramide (metoclopramide hydrochloride). Common drug interactions include insomnia among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Excedrin and Metoclopramide. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is often used in nausea. eHealthMe is studying from 81,263 Metoclopramide users. Check the latest studies of Metoclopramide.

On Aug, 07, 2026

72 people who take Excedrin and Metoclopramide together, and have interactions are studied.

Excedrin and Metoclopramide drug interactions.

What are the common drug interactions of Excedrin and Metoclopramide, by gender? *:

female:

Insomnia (sleeplessness)
Pneumonia
Sinusitis (inflammation of sinus)
Asthenia (weakness)
Chest pain
Chronic kidney disease
Diabetes mellitus inadequate control
Drug hypersensitivity
Dyskinesia (abnormality or impairment of voluntary movement)
Ear infection

male:

Diarrhoea
Back pain
General physical health deterioration (weak health status)
Hepatic steatosis (fatty liver disease)
Intestinal perforation (complete penetration of the wall of the intestine)
Large intestine perforation (hole in large intestine)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Nephrolithiasis (calculi in the kidneys)
Pancreatic pseudocyst (collection of tissue and fluids that forms on pancreas)
Pleural effusion (water on the lungs)

What are the common drug interactions of Excedrin and Metoclopramide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Abdominal discomfort
Gallbladder disorder
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Diarrhoea
Discomfort
Dizziness
Drug hypersensitivity
Fatigue (feeling of tiredness)

30-39:

Cerebral venous thrombosis (clot in brains venous blood system)
Death
Diabetes mellitus inadequate control
Diarrhoea
Dysphonia (speech disorder attributable to a disorder of phonation)
Ketoacidosis (high concentrations of ketone bodies in blood)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pharyngolaryngeal pain

40-49:

Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Abdominal pain upper
Abnormal loss of weight
Alcohol use
Anxiety
Aspartate aminotransferase increased
Blood pressure increased
Chronic kidney disease

50-59:

Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Ammonia increased
Arthropathy
Cervicobrachial syndrome (pain in neck and arm with changing location)
Chills (felling of cold)
Chronic kidney disease
Cold sweat
Diarrhoea
Emotional distress

60+:

Renal failure (kidney dysfunction)
Anxiety
Emotional disorder
Emotional distress
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Fall
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypertension (high blood pressure)
Hyperventilation

What are the existing conditions these people have? *

Pain: 8 people, 11.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 11.11%
Depression: 8 people, 11.11%
Stress And Anxiety: 7 people, 9.72%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 9.72%
Hypersensitivity: 6 people, 8.33%
Migraine (headache): 5 people, 6.94%
Birth Control: 5 people, 6.94%
Neoplasm Malignant (cancer tumour): 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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