Fentanyl transdermal system and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl transdermal system (fentanyl) and Flonase (fluticasone propionate). Common drug interactions include application site pruritus among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl transdermal system and Flonase. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl transdermal system?

Fentanyl transdermal system has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 5,728 Fentanyl transdermal system users. Check the latest studies of Fentanyl transdermal system.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

20 people who take Fentanyl transdermal system and Flonase together, and have interactions are studied.

Fentanyl transdermal system and Flonase drug interactions.

What are the common drug interactions of Fentanyl Transdermal System and Flonase, by gender? *:

female:

Application site pruritus (application site severe itching of the skin)
Death
Fall
Herpes zoster
Spinal compression fracture (fracture due to spinal compression on bone)
Accidental exposure
Adverse drug reaction
Adverse event
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Conjunctivitis (pink eye)

male:

Insomnia (sleeplessness)
Application site irritation
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Adverse event
Blood cholesterol increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Hypertension (high blood pressure)

What are the common drug interactions of Fentanyl Transdermal System and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Adverse event
Blood cholesterol increased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Hypertension (high blood pressure)
Spinal cord compression
Weight fluctuation
Accidental exposure
Application site rash
Blood creatinine increased
Conjunctivitis (pink eye)

50-59:

Pneumonia
Cold sweat
Dysuria (painful or difficult urination)
Eye disorder
Gastric disorder (disease of stomach)
Vitreous floaters (spots before the eyes)
Adverse event
Application site pruritus (application site severe itching of the skin)
Disease progression
Dizziness

60+:

Death
Application site pruritus (application site severe itching of the skin)
Nausea (feeling of having an urge to vomit)
Nervousness
Pain in extremity
Pain in jaw
Pyrexia (fever)
Rash macular (small, flat red spots)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Vomiting

What are the existing conditions these people have? *

Multiple Allergies (allergy to multiple agents): 6 people, 30.00%
Back Pain: 5 people, 25.00%
Sleep Disorder: 5 people, 25.00%
Breakthrough Pain: 4 people, 20.00%
Depression: 4 people, 20.00%
Diabetes: 3 people, 15.00%
High Blood Pressure: 3 people, 15.00%
Indigestion: 3 people, 15.00%
Lung Disorder (lung disease): 2 people, 10.00%
Asthma: 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Fentanyl transdermal system and Flonase?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously