Fentanyl and Divalproex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Divalproex (divalproex sodium). Common drug interactions include lung infection among females and serotonin syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Divalproex. It is created by eHealthMe based on reports of 73 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Divalproex?

Divalproex has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 14,063 Divalproex users. Check the latest studies of Divalproex.

On Jul, 30, 2026

73 people who take Fentanyl and Divalproex together, and have interactions are studied.

Fentanyl and Divalproex drug interactions.

What are the common drug interactions of Fentanyl and Divalproex, by gender? *:

female:

Lung infection
Metabolic alkalosis (too much bicarbonate in the blood)
Mobility decreased (ability to move is reduced)
Renal failure acute (rapid kidney dysfunction)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pain in extremity
Abdominal pain upper

male:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Agitation (state of anxiety or nervous excitement)
Bacterial infection
Febrile neutropenia (fever with reduced white blood cells)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Hypoxia (low oxygen in tissues)
Lung infection
Renal failure acute (rapid kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

What are the common drug interactions of Fentanyl and Divalproex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Joint dislocation (a joint position is changed from normal position)
Upper respiratory tract infection
Vomiting
Constipation
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Otitis media (inflammation of the middle ear)

10-19:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Agitation (state of anxiety or nervous excitement)
Syncope (loss of consciousness with an inability to maintain postural tone)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Blood creatine phosphokinase increased
Blood pressure increased
Confusional state
Flushing (the warm, red condition of human skin)
Heart rate increased

20-29:

Pulmonary embolism (blockage of the main artery of the lung)
Vomiting

30-39:

Hypokalaemia (low potassium)
Torsade de pointes (a abnormal heart rate with abnormal beating pattern)
Dyspnoea (difficult or laboured respiration)
Pulmonary embolism (blockage of the main artery of the lung)
Electrocardiogram qt prolonged
Metabolic alkalosis (too much bicarbonate in the blood)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Chest pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pain in extremity

40-49:

Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Multiple drug overdose intentional
Renal failure chronic (long lasting kidney dysfunction)
Renal pain (kidney pain)
Respiratory distress (difficulty in breathing)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Suicide attempt

50-59:

Death
Hypotension (abnormally low blood pressure)
Aspergillosis (an infection caused by a fungus called aspergillus)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Lung infection
Renal failure acute (rapid kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Bacterial infection
Device dislocation

60+:

Hypoxia (low oxygen in tissues)
Respiratory failure (inadequate gas exchange by the respiratory system)
Thrombocytopenia (decrease of platelets in blood)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Rash
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Death

What are the existing conditions these people have? *

Depression: 8 people, 10.96%
High Blood Pressure: 6 people, 8.22%
Sleep Disorder: 5 people, 6.85%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.85%
Multiple Myeloma (cancer of the plasma cells): 4 people, 5.48%
Back Pain: 4 people, 5.48%

* Approximation only. Some reports may have incomplete information.

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