Fentanyl and Methylphenidate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Methylphenidate (methylphenidate). Common drug interactions include maculopathy among females and unresponsive to stimuli among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Methylphenidate. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

On Jul, 17, 2026

35 people who take Fentanyl and Methylphenidate together, and have interactions are studied.

Fentanyl and Methylphenidate drug interactions.

What are the common drug interactions of Fentanyl and Methylphenidate, by gender? *:

female:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)

male:

Unresponsive to stimuli
Drug level increased
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Drug abuse
Overdose
Agitation (state of anxiety or nervous excitement)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Binocular eye movement disorder
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)

What are the common drug interactions of Fentanyl and Methylphenidate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug abuse

30-39:

Drug level increased
Overdose
Unresponsive to stimuli

40-49:

Agitation (state of anxiety or nervous excitement)
Unresponsive to stimuli
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Binocular eye movement disorder
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)
Hypertension (high blood pressure)
Hyperthermia (body temperature greatly above normal)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

50-59:

n/a

60+:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)

What are the existing conditions these people have? *

Depression: 3 people, 8.57%
Stress And Anxiety: 2 people, 5.71%
Multiple Allergies (allergy to multiple agents): 2 people, 5.71%
Infection: 2 people, 5.71%
Headache (pain in head): 2 people, 5.71%
Eye Disorder: 2 people, 5.71%
Cystitis Interstitial (unknown cause characterized by bladder pain): 2 people, 5.71%
Bladder Spasm: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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