Fentanyl and Palladone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fentanyl (fentanyl citrate) and Palladone (hydromorphone hydrochloride). Common drug interactions include drug dependence among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Fentanyl and Palladone. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Palladone?

Palladone has active ingredients of hydromorphone hydrochloride. eHealthMe is studying from 2,546 Palladone users. Check the latest studies of Palladone.

On Jul, 21, 2026

27 people who take Fentanyl and Palladone together, and have interactions are studied.

Fentanyl and Palladone drug interactions.

What are the common drug interactions of Fentanyl and Palladone, by gender? *:

female:

Drug dependence
Overdose
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Learning disability (difficulty in learning)
Mental disability
Brain injury
Cardiac arrest
Cardiomyopathy (weakening of the heart muscle)
Developmental delay
Fall

male:

Drug dependence
Overdose
Confusional state
Developmental delay
Disability
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Emotional distress
General physical health deterioration (weak health status)
Learning disability (difficulty in learning)
Respiratory depression (respiration has a rate below 12 breaths)

What are the common drug interactions of Fentanyl and Palladone, by age (0-1 to 60+)? *:

0-1:

Acidosis (build-up of carbon dioxide in the blood)
Respiratory depression (respiration has a rate below 12 breaths)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depression
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Endocrine disorder (endocrine diseases are disorders of the endocrine system)
Hyperaesthesia
Injury
Overdose
Post-traumatic stress disorder

40-49:

Adverse drug reaction
Application site erythema (redness of the skin at application site)
Application site irritation
Application site reaction
Asthenia (weakness)
Decreased appetite
Drug effect decreased
Drug effect increased
Drug ineffective
Dyspnoea (difficult or laboured respiration)

50-59:

Body temperature increased
Diarrhoea
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Suicidal ideation

60+:

Confusional state
Drug hypersensitivity
Eating disorder
Hepatotoxicity (chemical-driven liver damage)
Metastases to liver (cancer spreads to liver)
Nausea (feeling of having an urge to vomit)
Oedema mouth (swelling of mouth)
Pathological fracture (broken bone caused by disease)
Pneumonia
Psychotic disorder

* Approximation only. Some reports may have incomplete information.

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