Fioricet and Lansoprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fioricet (acetaminophen; butalbital; caffeine) and Lansoprazole (lansoprazole). Common drug interactions include intervertebral disc protrusion among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Fioricet and Lansoprazole. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Lansoprazole?

Lansoprazole has active ingredients of lansoprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 129,666 Lansoprazole users. Check the latest studies of Lansoprazole.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

61 people who take Fioricet and Lansoprazole together, and have interactions are studied.

Fioricet and Lansoprazole drug interactions.

What are the common drug interactions of Fioricet and Lansoprazole, by gender? *:

female:

Intervertebral disc protrusion (spinal disc protrusion)
Nasopharyngitis (inflammation of the nasopharynx)
Abdominal distension
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Cardiac disorder
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Depressed level of consciousness
Depression

male:

Asthenia (weakness)
Abdominal discomfort
Pancreatic duct obstruction
Decreased appetite
Sinusitis (inflammation of sinus)
Weight decreased
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Cough
Arthralgia (joint pain)

What are the common drug interactions of Fioricet and Lansoprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Exostosis (formation of new bone on the surface of a bone)
Hyperthyroidism (over activity of the thyroid gland)
Incontinence (lack of moderation or self-control)
Intervertebral disc protrusion (spinal disc protrusion)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

40-49:

Chronic kidney disease
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cardiac disorder
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Ear infection
Foot fracture
Infected cyst
Infusion site reaction
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)

50-59:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cough
Nasal septum perforation (hole in nasal septum)
Respiratory tract congestion (blockage on respiratory system)
Secretion discharge
Abdominal pain
Abdominal pain upper
Anaphylactic reaction (serious allergic reaction)
Anxiety
Ataxia (loss of full control of bodily movements)

60+:

Asthenia (weakness)
Abdominal discomfort
Insomnia (sleeplessness)
Weight decreased
Abdominal distension
Diarrhoea
Decreased appetite
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Dizziness
Fall

What are the existing conditions these people have? *

Pain: 11 people, 18.03%
Headache (pain in head): 11 people, 18.03%
High Blood Cholesterol: 10 people, 16.39%
Insomnia (sleeplessness): 9 people, 14.75%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 13.11%
Cardiac Disorder: 7 people, 11.48%
High Blood Pressure: 6 people, 9.84%
Abdominal Pain: 6 people, 9.84%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 9.84%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

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