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Fiorinal and Famotidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fiorinal (aspirin; butalbital; caffeine) and Famotidine (famotidine). Common drug interactions include contusion among females and affect lability among males.

The phase IV clinical study analyzes what interactions people have when they take Fiorinal and Famotidine. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Famotidine?

Famotidine has active ingredients of famotidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 83,421 Famotidine users. Check the latest studies of Famotidine.

On Jul, 20, 2026

20 people who take Fiorinal and Famotidine together, and have interactions are studied.

Fiorinal and Famotidine drug interactions.

What are the common drug interactions of Fiorinal and Famotidine, by gender? *:

female:

  1. Contusion (a type of hematoma of tissue in which capillaries)
  2. Dysphagia (a condition in which swallowing is difficult or painful)
  3. Fatigue (feeling of tiredness)
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Rash
  6. Sinusitis (inflammation of sinus)
  7. Glaucoma (increased fluid pressure in the eye with vision loss)
  8. Anaemia (lack of blood)
  9. Anxiety
  10. Blood pressure increased

male:

  1. Affect lability (emotional incontinence)
  2. Chronic kidney disease
  3. Depression
  4. Nephropathy (damage to or disease of a kidney)
  5. Renal failure (kidney dysfunction)
  6. Renal injury (kidney injury)
  7. Alanine aminotransferase increased
  8. Pyrexia (fever)

What are the common drug interactions of Fiorinal and Famotidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Affect lability (emotional incontinence)
  2. Chronic kidney disease
  3. Depression
  4. Nephropathy (damage to or disease of a kidney)
  5. Renal failure (kidney dysfunction)
  6. Renal injury (kidney injury)

30-39:

n/a

40-49:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Back pain
  3. Blood pressure decreased
  4. Bradycardia (abnormally slow heart action)
  5. Breath sounds
  6. Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
  7. Cardiac failure congestive
  8. Cardiac flutter (abnormal heart rhythm)
  9. Cardiomegaly (increased size of heart than normal)
  10. Chest discomfort

50-59:

  1. Chronic kidney disease
  2. Glaucoma (increased fluid pressure in the eye with vision loss)
  3. Nephropathy (damage to or disease of a kidney)
  4. Renal failure (kidney dysfunction)

60+:

  1. Contusion (a type of hematoma of tissue in which capillaries)
  2. Dysphagia (a condition in which swallowing is difficult or painful)
  3. Malaise (a feeling of general discomfort or uneasiness)
  4. Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
  5. Nasopharyngitis (inflammation of the nasopharynx)
  6. Nausea (feeling of having an urge to vomit)
  7. Sinusitis (inflammation of sinus)
  8. Surgery
  9. Urinary tract infection
  10. Weight decreased

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 2 people, 10.00%
  2. Nausea (feeling of having an urge to vomit): 2 people, 10.00%
  3. Headache (pain in head): 2 people, 10.00%
  4. High Blood Pressure: 2 people, 10.00%
  5. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 10.00%
  6. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 10.00%
  7. Bipolar Disorder (mood disorder): 2 people, 10.00%
  8. Ovarian Cancer (cancer of ovary): 2 people, 10.00%
  9. Nausea And Vomiting: 1 person, 5.00%
  10. Herpes Virus Infection: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Fiorinal and Famotidine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Fiorinal and Famotidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fiorinal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Famotidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fiorinal and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Famotidine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on aspirin; butalbital; caffeine and famotidine (the active ingredients of Fiorinal and Famotidine, respectively), and Fiorinal and Famotidine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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