Flector and Zanaflex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flector (diclofenac epolamine) and Zanaflex (tizanidine hydrochloride). Common drug interactions include bronchitis among females and memory impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Flector and Zanaflex. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Flector?

Flector has active ingredients of diclofenac epolamine. It is often used in pain. eHealthMe is studying from 5,112 Flector users. Check the latest studies of Flector.

What is Zanaflex?

Zanaflex has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 17,476 Zanaflex users. Check the latest studies of Zanaflex.

On Jul, 19, 2026

88 people who take Flector and Zanaflex together, and have interactions are studied.

What are the common drug interactions of Flector and Zanaflex, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Dystonia (abnormal muscle tone)
Fibula fracture
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gout (uric acid crystals building up in the body)
Headache (pain in head)

male:

Memory impairment
Abdominal pain
Headache (pain in head)
Muscular weakness (muscle weakness)
Therapeutic response unexpected
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal pain lower
Abscess (pus)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)

What are the common drug interactions of Flector and Zanaflex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abnormal behaviour
Aggression
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Logorrhoea (excessive, uncontrollable, or incoherent talkativeness)

30-39:

Abdominal pain
Abdominal pain lower
Abscess (pus)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Burning sensation
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Diarrhoea
Fluid retention (an abnormal accumulation of fluid in the blood)

40-49:

Memory impairment
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depression
Fall
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Gait disturbance
Pruritus (severe itching of the skin)

50-59:

Blood creatinine increased
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cellulitis (infection under the skin)
Escherichia sepsis (bacterial infection by escherichia coli)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Fall
Foot fracture
Glomerular filtration rate decreased
Hand fracture

60+:

Fall
Somnolence (a state of near-sleep, a strong desire for sleep)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Anaemia (lack of blood)
Balance disorder
Contusion (a type of hematoma of tissue in which capillaries)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dizziness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 25.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 21 people, 23.86%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 11.36%
Fibromyalgia (a long-term condition which causes pain all over the body): 9 people, 10.23%
Depression: 8 people, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 7.95%
High Blood Pressure: 7 people, 7.95%
High Blood Cholesterol: 7 people, 7.95%
Sleep Disorder: 7 people, 7.95%
Immunodeficiency Common Variable: 7 people, 7.95%

* Approximation only. Some reports may have incomplete information.

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