Flexeril and Buprenorphine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Buprenorphine (buprenorphine). Common drug interactions include hyperhidrosis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Buprenorphine. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Buprenorphine?

Buprenorphine has active ingredients of buprenorphine. It is often used in opioid intoxication. eHealthMe is studying from 9,053 Buprenorphine users. Check the latest studies of Buprenorphine.

On Jul, 06, 2026

17 people who take Flexeril and Buprenorphine together, and have interactions are studied.

Flexeril and Buprenorphine drug interactions.

What are the common drug interactions of Flexeril and Buprenorphine, by gender? *:

female:

Hyperhidrosis (abnormally increased sweating)
Anxiety
Cataract (clouding of the lens inside the eye)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Malaise (a feeling of general discomfort or uneasiness)
Application site erythema (redness of the skin at application site)
Application site irritation
Application site pruritus (application site severe itching of the skin)
Application site rash
Application site swelling

male:

Anxiety
Pain
Headache (pain in head)
Insomnia (sleeplessness)
Loss of employment
Lymphadenopathy (disease or enlargement of lymph nodes)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Tonsillitis (inflammation of tonsil)
Abdominal discomfort

What are the common drug interactions of Flexeril and Buprenorphine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Arthralgia (joint pain)
Bone density decreased
Decreased appetite
Depression
Dizziness
Dysstasia (difficulty in standing)
Emotional distress
Food aversion (we reject certain foods for a reason)
Fracture

40-49:

Application site erythema (redness of the skin at application site)
Application site irritation
Application site pruritus (application site severe itching of the skin)
Application site rash
Application site swelling
Application site vesicles (small bubble within a cell at application site)
Skin exfoliation (removal of the oldest dead skin cells)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood pressure increased
Chronic kidney disease
Emotional distress
Hot flush (sudden feelings of heat)
Pain
Stress

60+:

Cataract (clouding of the lens inside the eye)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Oedema peripheral (superficial swelling)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Anaemia (lack of blood)
Asthenia (weakness)
Bone pain
Cardiac failure congestive

What are the existing conditions these people have? *

Pain: 5 people, 29.41%
Stress And Anxiety: 4 people, 23.53%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 17.65%
High Blood Pressure: 3 people, 17.65%
Depression: 3 people, 17.65%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 17.65%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.76%
Hyperkalemia (damage to or disease of the kidney): 2 people, 11.76%
Hiv Infection: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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