Flexeril and Cataflam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Cataflam (diclofenac potassium). Common drug interactions include bile duct stone among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Cataflam. It is created by eHealthMe based on reports of 54 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Cataflam?

Cataflam has active ingredients of diclofenac potassium. It is often used in pain. eHealthMe is studying from 1,851 Cataflam users. Check the latest studies of Cataflam.

On Jul, 14, 2026

54 people who take Flexeril and Cataflam together, and have interactions are studied.

Flexeril and Cataflam drug interactions.

What are the common drug interactions of Flexeril and Cataflam, by gender? *:

female:

Bile duct stone
Biliary dilatation
Bleeding anovulatory
Blood chloride increased
Blood glucose decreased
Blood glucose increased
Blood pressure decreased
Blood urine present
Brain neoplasm (tumour of brain)
Burning sensation

male:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Oedema peripheral (superficial swelling)
Decreased appetite
Dizziness
Drug ineffective
Dysstasia (difficulty in standing)
Feeling drunk
Gait disturbance
Hepatitis (inflammation of the liver)

What are the common drug interactions of Flexeril and Cataflam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cholecystitis chronic (long lasting infection of gallbladder)
Depression
Emotional distress
Gallbladder disorder
Gallbladder pain
General physical health deterioration (weak health status)
Injury
Migraine (headache)

30-39:

Abdominal pain
Aphasia (damage to the parts of the brain that control language)
Blood chloride increased
Blood urine present
Calculus urinary (stone in urinary system)
Carbon dioxide decreased
Depression
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Emotional disorder

40-49:

Appendicitis (inflammation of the appendix)
Bedridden
Hyperhidrosis (abnormally increased sweating)
Hypersensitivity
Platelet count decreased
White blood cell count decreased
Activities of daily living impaired
Adjustment disorder with depressed mood
Asthenia (weakness)
Biliary dilatation

50-59:

Haemoglobin decreased
Hypersensitivity
Hypertension (high blood pressure)
Inflammation
Injection site bruising
Injection site pain
Injury
Limb injury
Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces)
Malaise (a feeling of general discomfort or uneasiness)

60+:

Confusional state
Hepatitis (inflammation of the liver)
Drug hypersensitivity
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)
Escherichia sepsis (bacterial infection by escherichia coli)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 24.07%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 14.81%
High Blood Pressure: 7 people, 12.96%
Insomnia (sleeplessness): 5 people, 9.26%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.41%
Depression: 4 people, 7.41%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 7.41%
Temporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 3 people, 5.56%
Skin Wrinkling (wrinkle on skin): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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