Flexeril and Nizoral drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Nizoral (ketoconazole). Common drug interactions include dizziness among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Nizoral. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Nizoral?

Nizoral has active ingredients of ketoconazole. It is often used in seborrheic dermatitis. eHealthMe is studying from 5,836 Nizoral users. Check the latest studies of Nizoral.

On Jul, 15, 2026

68 people who take Flexeril and Nizoral together, and have interactions are studied.

What are the common drug interactions of Flexeril and Nizoral, by gender? *:

female:

Dizziness
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
C-reactive protein increased
Headache (pain in head)
Hypersensitivity
Nausea (feeling of having an urge to vomit)
Upper respiratory tract infection
Abdominal distension
Abdominal pain upper

male:

Pain
Fatigue (feeling of tiredness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Constipation
Hyperlipidaemia (presence of excess lipids in the blood)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rectal cancer (cancer of rectum)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Abdominal pain

What are the common drug interactions of Flexeril and Nizoral, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal distension
Abdominal pain upper
Arthralgia (joint pain)
Atrioventricular block (heart block)
Bladder disorder
Blood bilirubin increased
Bradycardia (abnormally slow heart action)
Complication of device insertion
Decreased appetite
Delayed haemolytic transfusion reaction

30-39:

Breast cancer
Electrocardiogram qt corrected interval prolonged
Electrocardiogram qt prolonged
Hypersensitivity
Infusion related reaction
Pruritus (severe itching of the skin)

40-49:

Chest pain
Pain
Anxiety
Chest discomfort
Depression
Dyspnoea (difficult or laboured respiration)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Arthralgia (joint pain)
Bipolar disorder (mood disorder)

50-59:

General physical health deterioration (weak health status)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hypertensive nephropathy (hypertensive renal disease)
Temperature intolerance (inability to go in temperature)
Abdominal pain
Acute sinusitis
Anaemia (lack of blood)
Arthropathy
Asthenia (weakness)
Blood alkaline phosphatase increased

60+:

Fatigue (feeling of tiredness)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Weight decreased
Abdominal distension
Abdominal pain upper
Anaemia (lack of blood)
Asthenia (weakness)
Drug ineffective
Foot fracture

What are the existing conditions these people have? *

Pain: 17 people, 25.00%
High Blood Cholesterol: 10 people, 14.71%
Asthma: 8 people, 11.76%
High Blood Pressure: 7 people, 10.29%
Hiv Infection: 7 people, 10.29%
Constipation: 7 people, 10.29%
Depression: 7 people, 10.29%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 8.82%
Nausea (feeling of having an urge to vomit): 6 people, 8.82%
Hypersensitivity: 5 people, 7.35%

* Approximation only. Some reports may have incomplete information.

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