Flexeril and Riboflavin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Riboflavin (riboflavin (vitamin b2)). Common drug interactions include cough among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Riboflavin. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Riboflavin?

Riboflavin has active ingredients of riboflavin (vitamin b2). It is often used in migraine. eHealthMe is studying from 2,869 Riboflavin users. Check the latest studies of Riboflavin.

On Jul, 14, 2026

62 people who take Flexeril and Riboflavin together, and have interactions are studied.

Flexeril and Riboflavin drug interactions.

What are the common drug interactions of Flexeril and Riboflavin, by gender? *:

female:

Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea
Drug administration error
Dysarthria (speech disorder)
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dysphonia (speech disorder attributable to a disorder of phonation)
Ear pain

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Proteinuria (presence of protein in the urine)
Ankle fracture
Gait disturbance
Hypercoagulation (increased tendency for clotting of the blood)
Intervertebral disc protrusion (spinal disc protrusion)
Mobility decreased (ability to move is reduced)
Nerve compression
Osteonecrosis (death of bone)

What are the common drug interactions of Flexeril and Riboflavin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pulmonary embolism (blockage of the main artery of the lung)

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Ear pain
Headache (pain in head)
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins)
Pain
Pneumonia
Road traffic accident
Tinnitus (a ringing in the ears)

30-39:

Drug ineffective
Drug intolerance (drug sensitivity)
Headache (pain in head)
Hemianopia homonymous (visual field defect involving either the two right or the two left halves of the visual fields of both eyes)
Photophobia (extreme sensitivity to light)
Pruritus (severe itching of the skin)
Rash
Alopecia (absence of hair from areas of the body)
Basal ganglia infarction (disruption of the blood flow in the small blood vessels in the white matter of the cerebral cortex)
Cough

40-49:

Burning sensation
Overdose
Craniocerebral injury (injury to cranium and brain)
Candidiasis (candidiasis or thrush is a fungal infection)
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Fistula (an abnormal connection or passageway between two)
Hypotension (abnormally low blood pressure)

50-59:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Decreased activity
Depression
Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Quality of life decreased
Fatigue (feeling of tiredness)

60+:

Adverse event
Blood cholesterol increased
Dizziness
Drug administration error
Drug ineffective
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Heat exhaustion (dizziness and nausea and weakness caused by depletion of body fluids and electrolytes)
Kidney infection

What are the existing conditions these people have? *

Pain: 17 people, 27.42%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 17.74%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 16.13%
Hypersensitivity: 9 people, 14.52%
High Blood Pressure: 9 people, 14.52%
Asthma: 9 people, 14.52%
Insomnia (sleeplessness): 8 people, 12.90%
Sleep Disorder: 7 people, 11.29%
Nerve Injury: 7 people, 11.29%
Gastric Ulcer (stomach ulcer): 6 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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