Flexeril and Sular drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flexeril (cyclobenzaprine hydrochloride) and Sular (nisoldipine). Common drug interactions include insomnia among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Flexeril and Sular. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

What is Sular?

Sular has active ingredients of nisoldipine. It is often used in high blood pressure. eHealthMe is studying from 1,757 Sular users. Check the latest studies of Sular.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

22 people who take Flexeril and Sular together, and have interactions are studied.

What are the common drug interactions of Flexeril and Sular, by gender? *:

female:

Insomnia (sleeplessness)
Irritable bowel syndrome
Kidney infection
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Myalgia (muscle pain)
Nail disorder (disease of nail)
Nervousness
Obesity (having too much body fat)
Osteoporosis (bones weak and more likely to break)
Pain

male:

Abdominal pain
Dyspnoea (difficult or laboured respiration)
Myalgia (muscle pain)
Pain in extremity
Pallor
Vomiting
Aspartate aminotransferase increased
Blood glucose increased
Colitis (inflammation of colon)
Drug hypersensitivity

What are the common drug interactions of Flexeril and Sular, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anaemia (lack of blood)
Anxiety
Asthenia (weakness)
Cardiac failure congestive
Device dislocation
Dystonia (abnormal muscle tone)
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

30-39:

Blood pressure fluctuation
Diarrhoea
Dizziness
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Loss of consciousness
Pallor
Thrombocytopenia (decrease of platelets in blood)

40-49:

n/a

50-59:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Asthma
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Depression
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Ear pain
Flushing (the warm, red condition of human skin)
Headache (pain in head)

60+:

Abdominal pain
Myalgia (muscle pain)
Acute stress disorder
Blood alkaline phosphatase increased
Cardiac failure congestive
Chest pain
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 4 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.09%
Pain: 2 people, 9.09%
Headache (pain in head): 2 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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