Flonase and Activella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flonase (fluticasone propionate) and Activella (estradiol; norethindrone acetate). Common drug interactions include breast cancer female among females.

The phase IV clinical study analyzes what interactions people have when they take Flonase and Activella. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

What is Activella?

Activella has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 1,971 Activella users. Check the latest studies of Activella.

On Jul, 09, 2026

34 people who take Flonase and Activella together, and have interactions are studied.

Flonase and Activella drug interactions.

What are the common drug interactions of Flonase and Activella, by gender? *:

female:

Breast cancer female
Diarrhoea
Abdominal pain
Asthenia (weakness)
Hepatomegaly (abnormal enlargement of the liver)
Nausea (feeling of having an urge to vomit)
Rash
Pain
Alanine aminotransferase increased
Aspartate aminotransferase increased

male:

n/a

What are the common drug interactions of Flonase and Activella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Obesity (having too much body fat)

30-39:

n/a

40-49:

Bone density decreased
Depression

50-59:

Breast cancer female
Breast cancer
Chest pain
Bone density decreased
Anxiety
Appendicitis (inflammation of the appendix)
Cardiac disorder
Depression
Fatigue (feeling of tiredness)
Headache (pain in head)

60+:

Confusional state
Enteritis (inflammation of the small intestine)
Bowen's disease (early stage of skin cancer)
Cystitis (inflammation of the wall of the bladder)
Euphoric mood (excessively happy but may become angry or irritable)
Fall
Fatigue (feeling of tiredness)
Joint injury
Nausea (feeling of having an urge to vomit)
Vomiting

What are the existing conditions these people have? *

Seasonal Allergy (allergic condition due to certain season): 7 people, 20.59%
Colon Cancer: 5 people, 14.71%
Stress And Anxiety: 5 people, 14.71%
Migraine (headache): 5 people, 14.71%
Depression: 5 people, 14.71%
Urticaria (rash of round, red welts on the skin that itch intensely): 4 people, 11.76%
Sinusitis (inflammation of sinus): 4 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.76%
Nerve Injury: 4 people, 11.76%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 4 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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