Flonase and Kineret drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Flonase (fluticasone propionate) and Kineret (anakinra). Common drug interactions include pyrexia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Flonase and Kineret. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

What is Kineret?

Kineret has active ingredients of anakinra. It is often used in rheumatoid arthritis. eHealthMe is studying from 11,120 Kineret users. Check the latest studies of Kineret.



On Jul, 12, 2026

34 people who take Flonase and Kineret together, and have interactions are studied.

Flonase and Kineret drug interactions.

What are the common drug interactions of Flonase and Kineret, by gender? *:

female:

  1. Pyrexia (fever)
  2. Rash macular (small, flat red spots)
  3. Renal impairment (severely reduced kidney function)
  4. Seroma (a tumour like collection of serum in the tissues)
  5. Skin depigmentation (lightening of the skin)
  6. Spinal compression fracture (fracture due to spinal compression on bone)
  7. Throat tightness
  8. Vertigo
  9. Vision blurred
  10. Wheezing (a high-pitched whistling sound made while you breath)

male:

  1. Pyrexia (fever)
  2. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  3. Dyspnoea (difficult or laboured respiration)
  4. Nasopharyngitis (inflammation of the nasopharynx)
  5. Secretion discharge
  6. Viral infection
  7. Atelectasis (partial or complete collapse of the lung)
  8. Blood fibrinogen increased
  9. Blood pressure diastolic increased
  10. Blood pressure systolic increased

What are the common drug interactions of Flonase and Kineret, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Blood glucose decreased
  2. Immune system disorder
  3. Influenza
  4. Malaise (a feeling of general discomfort or uneasiness)
  5. Pneumonia

30-39:

  1. Headache (pain in head)
  2. Nausea (feeling of having an urge to vomit)
  3. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  4. Conjunctivitis (pink eye)
  5. Diarrhoea
  6. Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
  7. Herpes zoster
  8. Injection site erythema (redness at injection site)
  9. Injection site swelling
  10. Kidney infection

40-49:

  1. Dyspnoea (difficult or laboured respiration)
  2. Nasopharyngitis (inflammation of the nasopharynx)
  3. Secretion discharge
  4. Viral infection
  5. Diplopia (double vision)
  6. Vision blurred

50-59:

n/a

60+:

  1. Urticaria (rash of round, red welts on the skin that itch intensely)
  2. Chills (felling of cold)
  3. Blood pressure systolic increased
  4. C-reactive protein increased
  5. Coagulopathy (blood's ability to clot is impaired)
  6. Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
  7. Diarrhoea
  8. Fibrin d dimer increased
  9. Haemoglobin decreased
  10. Injection site discolouration

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 8 people, 23.53%
  2. Humoral Immune Defect (impairment of humoral immunity): 7 people, 20.59%
  3. Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 2 people, 5.88%
  4. Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Flonase and Kineret:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Flonase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Kineret:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Flonase and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Kineret and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on fluticasone propionate and anakinra (the active ingredients of Flonase and Kineret, respectively), and Flonase and Kineret (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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