Florinef and Dexamethasone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Florinef (fludrocortisone acetate) and Dexamethasone (dexamethasone). Common drug interactions include gait disturbance among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Florinef and Dexamethasone. It is created by eHealthMe based on reports of 94 people who take the same drugs from the FDA, and is updated regularly.

What is Florinef?

Florinef has active ingredients of fludrocortisone acetate. It is often used in addison's disease. eHealthMe is studying from 3,834 Florinef users. Check the latest studies of Florinef.

What is Dexamethasone?

Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 161,927 Dexamethasone users. Check the latest studies of Dexamethasone.

On Jul, 09, 2026

94 people who take Florinef and Dexamethasone together, and have interactions are studied.

Florinef and Dexamethasone drug interactions.

What are the common drug interactions of Florinef and Dexamethasone, by gender? *:

female:

Gait disturbance
Metastases to bone (cancer spreads to bone)
Nausea (feeling of having an urge to vomit)
Abdominal pain upper
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dehydration (dryness resulting from the removal of water)
Eating disorder
Emotional distress
Fall

male:

Dehydration (dryness resulting from the removal of water)
Haemoglobin decreased
Metastases to bone (cancer spreads to bone)
Oedema peripheral (superficial swelling)
Anal fistula
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

What are the common drug interactions of Florinef and Dexamethasone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pain
Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Back pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Dizziness
Emotional distress

20-29:

Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)

30-39:

Gastritis (inflammation of stomach)
Headache (pain in head)
Heart rate decreased
Heart rate increased
Migraine (headache)
Pancreatitis (inflammation of pancreas)
Neoplasm (tumour)
Blood cholesterol increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Blood prolactin increased

40-49:

Asthenia (weakness)
Blindness unilateral
Cholecystitis acute (rapid infection of gallbladder)
Deafness
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Meningioma benign (non cancer tumour of membranes that cover the brain and spinal cord just inside the skull)
Oedema peripheral (superficial swelling)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Pyrexia (fever)
Abdominal pain

50-59:

Fall
Fatigue (feeling of tiredness)
Gingival bleeding (bleeding gums)
Hip fracture
Hypophagia (reduced food intake)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Upper-airway cough syndrome
Actinomycosis (infection that causes sores, or abscesses)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

60+:

Dehydration (dryness resulting from the removal of water)
Haemoglobin decreased
Metastases to bone (cancer spreads to bone)
Pain
Renal failure acute (rapid kidney dysfunction)
Abdominal pain
Anal fistula
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)

What are the existing conditions these people have? *

Type 2 Diabetes: 8 people, 8.51%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 7 people, 7.45%
Constipation: 6 people, 6.38%
Pain: 5 people, 5.32%
Migraine (headache): 5 people, 5.32%

* Approximation only. Some reports may have incomplete information.

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