Floxin and Paxil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Floxin (ofloxacin) and Paxil (paroxetine hydrochloride). Common drug interactions include bronchospasm among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Floxin and Paxil. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Floxin?

Floxin has active ingredients of ofloxacin. eHealthMe is studying from 1,737 Floxin users. Check the latest studies of Floxin.

What is Paxil?

Paxil has active ingredients of paroxetine hydrochloride. It is often used in depression. eHealthMe is studying from 92,546 Paxil users. Check the latest studies of Paxil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

24 people who take Floxin and Paxil together, and have interactions are studied.

What are the common drug interactions of Floxin and Paxil, by gender? *:

female:

Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiac murmur (an heart sound in valve abnormality)
Diarrhoea
Chest pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Oedema lower limb (fluid collection in tissue of lower leg)
Back pain
Constipation
Dysuria (painful or difficult urination)

male:

Completed suicide (act of taking one's own life)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus inadequate control
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Hyperglycaemia (high blood sugar)
Hyperthyroidism (over activity of the thyroid gland)
Type 2 diabetes mellitus

What are the common drug interactions of Floxin and Paxil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain
Cytogenetic abnormality
Depressed mood
Diarrhoea
Dyslipidaemia (abnormal amount of lipids)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Headache (pain in head)
Hidradenitis (chronic disease of a type of sweat gland)

30-39:

Dyspnoea (difficult or laboured respiration)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiac murmur (an heart sound in valve abnormality)
Palpitations (feelings or sensations that your heart is pounding or racing)
Oedema lower limb (fluid collection in tissue of lower leg)
Blood pressure increased
Blood sodium increased
Cardiomegaly (increased size of heart than normal)
Chest pain

40-49:

Panic reaction
Pneumonia
Rash
Road traffic accident
Skin lesion
Suicidal ideation
Tinnitus (a ringing in the ears)
Type 2 diabetes mellitus
Upper respiratory tract infection
Urinary tract infection

50-59:

Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Angiopathy (generic term for a disease of the blood vessels)
Cardiac arrest
Cardiac failure congestive
Carotid artery disease
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Fall

60+:

Completed suicide (act of taking one's own life)
Constipation
Diplopia (double vision)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Disturbance in attention
Dyspepsia (indigestion)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Generalised oedema (swelling all over the body)

What are the existing conditions these people have? *

Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 2 people, 8.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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