Fomepizole and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fomepizole (fomepizole) and Acetaminophen (acetaminophen). Common drug interactions include hypotension among females and overdose among males.

The phase IV clinical study analyzes what interactions people have when they take Fomepizole and Acetaminophen. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Fomepizole?

Fomepizole has active ingredients of fomepizole. eHealthMe is studying from 155 Fomepizole users. Check the latest studies of Fomepizole.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 05, 2026

37 people who take Fomepizole and Acetaminophen together, and have interactions are studied.

Fomepizole and Acetaminophen drug interactions.

What are the common drug interactions of Fomepizole and Acetaminophen, by gender? *:

female:

Hypotension (abnormally low blood pressure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Overdose
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Hepatotoxicity (chemical-driven liver damage)
Drug ineffective
Encephalopathy (functioning of the brain is affected by some agent or condition)
Liver injury
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

male:

Overdose
Hepatotoxicity (chemical-driven liver damage)
Hypotension (abnormally low blood pressure)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)
Coagulopathy (blood's ability to clot is impaired)
Coma (state of unconsciousness lasting more than six hours)
Drug ineffective
Electrocardiogram qrs complex prolonged
Electrocardiogram qt prolonged
Hypoglycaemia (deficiency of glucose in the bloodstream)

What are the common drug interactions of Fomepizole and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Abdominal pain
Overdose
Vomiting
Brain death
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
International normalised ratio increased

20-29:

Anion gap increased
Bradycardia (abnormally slow heart action)
Coagulopathy (blood's ability to clot is impaired)
Coma (state of unconsciousness lasting more than six hours)
Drug ineffective
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hypotension (abnormally low blood pressure)
Leukocytosis (increased white blood cells)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

30-39:

Hepatotoxicity (chemical-driven liver damage)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Acidosis (build-up of carbon dioxide in the blood)
Hypertension (high blood pressure)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Overdose
Tachypnoea (a condition of rapid breathing over 20 per minute)
Hypotension (abnormally low blood pressure)
Drug ineffective
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

40-49:

Overdose
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)

50-59:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Liver injury
Hepatotoxicity (chemical-driven liver damage)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Hepatorenal syndrome (renal failure in patients with advanced chronic liver disease)
Renal tubular necrosis (death of kidney tubules)
Coma (state of unconsciousness lasting more than six hours)
Drug ineffective
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)

60+:

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Coagulopathy (blood's ability to clot is impaired)
Coma (state of unconsciousness lasting more than six hours)
Drug ineffective
Electrocardiogram qrs complex prolonged
Electrocardiogram qt prolonged
Hyperkalaemia (damage to or disease of the kidney)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

What are the existing conditions these people have? *

Overdose: 21 people, 56.76%
Acute Hepatic Failure: 5 people, 13.51%
Toothaches (tooth pain): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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