Fortaz and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fortaz (ceftazidime) and Methotrexate (methotrexate sodium). Common drug interactions include leukopenia among females and confusion among males.

The phase IV clinical study analyzes what interactions people have when they take Fortaz and Methotrexate. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Fortaz?

Fortaz has active ingredients of ceftazidime. eHealthMe is studying from 980 Fortaz users. Check the latest studies of Fortaz.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

On Jul, 14, 2026

46 people who take Fortaz and Methotrexate together, and have interactions are studied.

Fortaz and Methotrexate drug interactions.

What are the common drug interactions of Fortaz and Methotrexate, by gender? *:

female:

Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Septic shock (shock due to blood infection)
Ureteric obstruction
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Acute myocardial infarction (acute heart attack)
Acute pulmonary oedema (sudden deposit of fluid in the lung))

male:

Confusion
Coordination abnormal (abnormal movement)
Body temperature increased
Bradycardia (abnormally slow heart action)
Caecitis (inflammation of the cecum)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Catheter related infection
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Clostridium colitis (inflammation of colon by clostridium difficile bacteria infection)

What are the common drug interactions of Fortaz and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Confusion
Coordination abnormal (abnormal movement)
Dysarthria (speech disorder)
Dystonia (abnormal muscle tone)
Apnoea (suspension of external breathing)
Blood culture positive
Blood pressure fluctuation

10-19:

Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Acute respiratory distress syndrome
Blood bilirubin increased
Hypotension (abnormally low blood pressure)
Hypernatraemia (an abnormally high plasma concentration of sodium ions)
Pneumonia respiratory syncytial viral (respiratory syncytial virus (rsv) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children)
Blood sodium increased
Lung infection
Abdominal abscess (collection of pus in abdomen)
Anastomotic leak

20-29:

Blood alkaline phosphatase increased
Blood creatinine increased
Crystal urine present
Gamma-glutamyltransferase increased
Leukaemia recurrent (repeat cancer of bone marrow or blood cells)
Pancreatitis acute (sudden inflammation of pancreas)

30-39:

n/a

40-49:

Febrile neutropenia (fever with reduced white blood cells)
Osteomyelitis (infection of bone)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Plantar fasciitis (painful inflammatory process of the plantar fascia)
Pneumonia
Rash pruritic (redness with itching)
Benign neoplasm of thyroid gland (benign (non-cancerous) tumours of the thyroid gland)
Colon neoplasm (cancer from uncontrolled cell growth in the colon or rectum)
Decreased interest

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Jugular vein thrombosis (clot in jugular vein)

60+:

Abdominal pain
Dyspnoea (difficult or laboured respiration)
Bone disorder
Colon neoplasm (cancer from uncontrolled cell growth in the colon or rectum)
Colonic obstruction (obstruction in colon)
Decreased interest
Defaecation urgency (a sudden compelling urge to defecate)
Depression
Dysfunctional uterine bleeding
Emotional distress

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 12 people, 26.09%
Nausea (feeling of having an urge to vomit): 11 people, 23.91%
Pain: 10 people, 21.74%
Constipation: 10 people, 21.74%
Chills (felling of cold): 9 people, 19.57%
Multiple Allergies (allergy to multiple agents): 9 people, 19.57%
Sedation: 9 people, 19.57%
Dry Skin: 9 people, 19.57%
Cough: 9 people, 19.57%
Agitation (state of anxiety or nervous excitement): 8 people, 17.39%

* Approximation only. Some reports may have incomplete information.

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