Fosamax and Tobi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fosamax (alendronate sodium) and Tobi (tobramycin). Common drug interactions include humerus fracture among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Fosamax and Tobi. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 105,452 Fosamax users. Check the latest studies of Fosamax.

What is Tobi?

Tobi has active ingredients of tobramycin. eHealthMe is studying from 10,011 Tobi users. Check the latest studies of Tobi.

On Jul, 12, 2026

32 people who take Fosamax and Tobi together, and have interactions are studied.

What are the common drug interactions of Fosamax and Tobi, by gender? *:

female:

Humerus fracture (injury to the upper arm bone)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Loss of consciousness
Lung neoplasm (tumour of lung)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Obesity (having too much body fat)
Postmenopausal haemorrhage (post-menopausal bleeding)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Rib fracture
Spinal claudication (leg pain with walking due to discomfort in spine)

male:

Anxiety
Respiratory failure (inadequate gas exchange by the respiratory system)
Blood alkaline phosphatase increased
Alanine aminotransferase increased
Aspartate aminotransferase increased
Gamma-glutamyltransferase increased
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Constipation
Lung infection
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)

What are the common drug interactions of Fosamax and Tobi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cystic fibrosis (disease of the secretary glands)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Influenza
Constipation
Gamma-glutamyltransferase increased
Lung infection
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
Respiratory failure (inadequate gas exchange by the respiratory system)

30-39:

Anxiety
Cough
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pulmonary function test decreased
Respiratory failure (inadequate gas exchange by the respiratory system)
Parasitic gastroenteritis (inflammation of the digestive tract by parasite infection)
Sputum discoloured

40-49:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Asthenia (weakness)
Chest discomfort
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Pneumonia
Respiratory syncytial virus infection (viral disease of respiratory system)

50-59:

Colonic polyp (extra part of colon tissue grow in intestine)
Depression
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Ear infection
Eye disorder
Fatigue (feeling of tiredness)
Femur fracture
Gastroenteritis (inflammation of stomach and intestine)
Gingival disorder (gum disease)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

60+:

Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pyrexia (fever)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood cholesterol increased
Body height decreased
Breast disorder
Cardiac failure congestive
Cardiac murmur (an heart sound in valve abnormality)
Cardiac valve disease (heart valve disease)

What are the existing conditions these people have? *

Cystic Fibrosis (disease of the secretary glands): 25 people, 78.12%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 7 people, 21.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 21.88%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 4 people, 12.50%
Obstructive Airways Disorder (a progressive disease that makes it hard to breathe): 4 people, 12.50%
Cystic Fibrosis Related Diabetes: 4 people, 12.50%
Sleep Disorder: 2 people, 6.25%
Constipation: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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