Fosamax and Vyvanse drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Fosamax (alendronate sodium) and Vyvanse (lisdexamfetamine dimesylate). Common drug interactions include gastroenteritis viral among females and pulmonary oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Fosamax and Vyvanse. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 105,452 Fosamax users. Check the latest studies of Fosamax.

What is Vyvanse?

Vyvanse has active ingredients of lisdexamfetamine dimesylate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 35,870 Vyvanse users. Check the latest studies of Vyvanse.

On Aug, 04, 2026

27 people who take Fosamax and Vyvanse together, and have interactions are studied.

What are the common drug interactions of Fosamax and Vyvanse, by gender? *:

female:

Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Glucose urine present
Infusion related reaction
Intestinal obstruction
Micturition disorder (disease of passing urine)
Nasopharyngitis (inflammation of the nasopharynx)
Nocturia (the need to get up in the night to urinate)
Rectal discharge (discharge from rectum)
Respiratory rate decreased (less breathing rate/min)
Rhinorrhoea (watery mucus discharge from the nose)

male:

Pulmonary oedema (fluid accumulation in the lungs)
Abdominal pain
Cardiomyopathy (weakening of the heart muscle)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cerebral calcification (abnormal deposits of calcium in certain areas of the brain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Coagulopathy (blood's ability to clot is impaired)
Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Death
Decreased appetite

What are the common drug interactions of Fosamax and Vyvanse, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Lymphoedema (localized fluid retention and tissue swelling)
Metastases to bone (cancer spreads to bone)
Metastases to spine (cancer spreads to spine)
Micturition disorder (disease of passing urine)
Micturition urgency (urgency to pass the urine)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Nocturia (the need to get up in the night to urinate)
Oedema peripheral (superficial swelling)

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Fall
Arthralgia (joint pain)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain
Apathy
Asthenia (weakness)
Blood pressure systolic increased
Chronic kidney disease
Drug effect decreased
Drug effect increased

60+:

Cough
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal injury (kidney injury)
Swelling face
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Blood pressure increased
Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the existing conditions these people have? *

Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 14.81%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 14.81%
Depression: 4 people, 14.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 14.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 11.11%
Stress And Anxiety: 2 people, 7.41%
Migraine (headache): 2 people, 7.41%
High Blood Pressure: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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