Fycompa and Keppra xr drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Fycompa (perampanel) and Keppra xr (levetiracetam). Common drug interactions include weight increased among females and balance disorder among males.
The phase IV clinical study analyzes what interactions people have when they take Fycompa and Keppra xr. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.
What is Fycompa?
Fycompa has active ingredients of perampanel. eHealthMe is studying from 4,387 Fycompa users. Check the latest studies of Fycompa.
What is Keppra xr?
Keppra xr has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 2,272 Keppra xr users. Check the latest studies of Keppra xr.
34 people who take Fycompa and Keppra xr together, and have interactions are studied.

What are the common drug interactions of Fycompa and Keppra Xr, by gender? *:
female:
- Weight increased
- Balance disorder
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Anxiety
- Breast cancer
- Drug ineffective
- Dysphagia (a condition in which swallowing is difficult or painful)
- Memory impairment
- Overdose
male:
- Balance disorder
- Constipation
- Irritability
- Overdose
- Partial seizures (seizures which affect only a part of the brain at onset)
- Fatigue (feeling of tiredness)
- Pneumonia
- Respiratory disorder (respiratory disease)
- Suicidal ideation
- Aggression
What are the common drug interactions of Fycompa and Keppra Xr, by age (0-1 to 60+)? *:
0-1:
- Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
- Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
- Urticaria (rash of round, red welts on the skin that itch intensely)
2-9:
n/a
10-19:
- Tremor (trembling or shaking movements in one or more parts of your body)
20-29:
- Weight increased
- Aggression
- Irritability
30-39:
- Anticonvulsant drug level decreased
- Death
- Drug hypersensitivity
- Overdose
40-49:
- Aphasia (damage to the parts of the brain that control language)
- Dizziness
- Fatigue (feeling of tiredness)
- Gait disturbance
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Complex partial seizures (epileptic seizure)
50-59:
- Suicidal ideation
60+:
- Balance disorder
- Constipation
- Vision blurred
- Fatigue (feeling of tiredness)
- Partial seizures (seizures which affect only a part of the brain at onset)
- Breast cancer
- Drug ineffective
- Dysphagia (a condition in which swallowing is difficult or painful)
- Memory impairment
- Overdose
What are the existing conditions these people have? *
- Seizures (abnormal excessive or synchronous neuronal activity in the brain): 13 people, 38.24%
- Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 9 people, 26.47%
- Partial Seizures (seizures which affect only a part of the brain at onset): 5 people, 14.71%
- Polyarthritis (arthritis which involves 5 or more joints simultaneously): 4 people, 11.76%
* Approximation only. Some reports may have incomplete information.
Do you take Fycompa and Keppra xr?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Fycompa and Keppra xr:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Fycompa:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Keppra xr:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Fycompa and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Keppra xr and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
- Schattner A, Al-Bewerat A, "Levetiracetam (Keppra), urinary retention and literature search", A fatty cause of renal failure; what is your diagnosis?, 2016 Oct .
- Spengler DC, Montouris GD, Hohler AD, "Levetiracetam as a possible contributor to acute kidney injury", Clinical therapeutics, 2014 Aug .
- Almeida DM, Jean MR, Chystsiakova A, Monahan E, Oliveira SB, Monteiro IM, "Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report", Pancreas, 2013 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on perampanel and levetiracetam (the active ingredients of Fycompa and Keppra xr, respectively), and Fycompa and Keppra xr (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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