Genvoya and Zyrtec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Genvoya (cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide fumarate) and Zyrtec (cetirizine hydrochloride). Common drug interactions include dermatitis atopic among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Genvoya and Zyrtec. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Genvoya?

Genvoya has active ingredients of cobicistat; elvitegravir; emtricitabine; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 13,538 Genvoya users. Check the latest studies of Genvoya.

What is Zyrtec?

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. eHealthMe is studying from 114,619 Zyrtec users. Check the latest studies of Zyrtec.

On Jul, 18, 2026

72 people who take Genvoya and Zyrtec together, and have interactions are studied.

What are the common drug interactions of Genvoya and Zyrtec, by gender? *:

female:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Mobility decreased (ability to move is reduced)
Multiple fractures
Neck mass (mass in neck)
Weight increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Bone loss
Depression
Fatigue (feeling of tiredness)
Acne cystic (skin problems that cause pimples)
Cellulitis (infection under the skin)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

What are the common drug interactions of Genvoya and Zyrtec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injury
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Bone loss
Osteonecrosis (death of bone)
Osteopenia (a condition where bone mineral density is lower than normal)

30-39:

Acne cystic (skin problems that cause pimples)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Hospitalisation
Infusion site erythema (reddening of the skin at infusion site)
Infusion site infection
Infusion site pain
Infusion site swelling
Oedema peripheral (superficial swelling)
Skin infection
Back pain

40-49:

Fatigue (feeling of tiredness)
Hypertension (high blood pressure)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal impairment (severely reduced kidney function)
Spinal fracture (fracture in one of vertebrae)
Vitamin d deficiency
Adverse drug reaction
Arthralgia (joint pain)
Bipolar disorder (mood disorder)
Blood creatinine increased

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Chronic kidney disease
Bone density decreased
Osteopenia (a condition where bone mineral density is lower than normal)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cellulitis (infection under the skin)
Osteoporosis (bones weak and more likely to break)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Hypoaesthesia (reduced sense of touch or sensation)
Osteoporosis (bones weak and more likely to break)
Application site erythema (redness of the skin at application site)
Application site pain
Application site rash
Application site swelling
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)

What are the existing conditions these people have? *

Hypersensitivity: 15 people, 20.83%
Psoriasis (immune-mediated disease that affects the skin): 7 people, 9.72%
High Blood Cholesterol: 7 people, 9.72%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 9.72%
Stress And Anxiety: 6 people, 8.33%
High Blood Pressure: 6 people, 8.33%
Pain: 5 people, 6.94%
Muscle Aches (muscle pain): 5 people, 6.94%
Immunodeficiency Common Variable: 5 people, 6.94%
Infection: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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