Lybalvi and Weight decreased - a phase IV clinical study of FDA data

Summary:

Weight decreased is reported as a side effect among people who take Lybalvi (olanzapine; samidorphan l-malate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Olanzapine, and have Schizophrenia.

The phase IV clinical study analyzes which people have Weight decreased when taking Lybalvi. It is created by eHealthMe based on reports of 872 people who have side effects when taking Lybalvi from the FDA, and is updated regularly.

What is Lybalvi?

Lybalvi has active ingredients of olanzapine; samidorphan l-malate. eHealthMe is studying from 874 Lybalvi users. Check the latest studies of Lybalvi.

What is Weight decreased?

Weight decreased is found to be associated with 3,392 drugs and 4,747 conditions by eHealthMe. Check the latest studies of Weight decreased.

On Jul, 18, 2026

872 people reported to have side effects when taking Lybalvi.
Among them, 39 people (4.47%) have Weight decreased.

Among these 39 people:

How long have people been on Lybalvi when they have Weight decreased? *

What is the gender of people who have Weight decreased when taking Lybalvi? *

female: 52.78 %
male: 47.22 %

What is the age of people who have Weight decreased when taking Lybalvi? *

What are other drugs people take besides Lybalvi? *

Olanzapine: 3 people, 7.69%
Haloperidol Decanoate: 1 person, 2.56%
Cymbalta: 1 person, 2.56%
Aristada: 1 person, 2.56%

What are other side effects people have besides Weight decreased? *

Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 23 people, 58.97%
Nausea And Vomiting: 3 people, 7.69%
Nausea (feeling of having an urge to vomit): 2 people, 5.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 2.56%
Bedwetting: 1 person, 2.56%
Blood Bilirubin Increased: 1 person, 2.56%
Dehydration (dryness resulting from the removal of water): 1 person, 2.56%
Diabetes: 1 person, 2.56%
Diarrhea: 1 person, 2.56%
Drooling (drop saliva uncontrollably from the mouth): 1 person, 2.56%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 13 people, 33.33%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 10 people, 25.64%
Bipolar Disorder (mood disorder): 3 people, 7.69%
Sleep Disorder: 1 person, 2.56%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 1 person, 2.56%
High Blood Pressure: 1 person, 2.56%

* Approximation only. Some reports may have incomplete information.

Do you take Lybalvi and have Weight decreased?

- Check whether Weight decreased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lybalvi:

Lybalvi (874 reports)

Weight decreased treatments and more:

Weight decreased (364,522 reports)

How severe was Weight decreased and when was it recovered:

Weight decreased in Lybalvi

Expand to all the drugs that have ingredients of olanzapine; samidorphan l-malate:

Weight decreased and drugs with ingredients of olanzapine; samidorphan l-malate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lybalvi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight decreased:

Weight decreased (3,392 drugs)

Browse all the conditions that are associated with Weight decreased:

Weight decreased (4,747 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on olanzapine; samidorphan l-malate (the active ingredients of Lybalvi) and Lybalvi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.