Glyburide and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Glyburide (glyburide) and Sinemet (carbidopa; levodopa). Common drug interactions include tooth extraction among females and blood glucose decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Glyburide and Sinemet. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Glyburide?

Glyburide has active ingredients of glyburide. It is often used in diabetes. eHealthMe is studying from 38,448 Glyburide users. Check the latest studies of Glyburide.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 09, 2026

96 people who take Glyburide and Sinemet together, and have interactions are studied.

Glyburide and Sinemet drug interactions.

What are the common drug interactions of Glyburide and Sinemet, by gender? *:

female:

Tooth extraction
Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Jaw disorder (jaw disease)
Joint range of motion decreased (disease of joint movement)
Nausea (feeling of having an urge to vomit)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess

male:

Blood glucose decreased
Pain
Endotracheal intubation complication
Haematocrit decreased
Haemoglobin decreased
Laryngeal oedema (swelling of larynx)
Pneumomediastinum (air is present in the mediastinum)
Screaming (a long loud piercing cry)
Stridor
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Glyburide and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Vulval abscess
Vulval cellulitis (inflammation of skin around vagina)
Vulvitis (inflammation of the vulva)

50-59:

Dyspnoea (difficult or laboured respiration)
Granulocytopenia (lack of granulocyte)
Irritability
Malaise (a feeling of general discomfort or uneasiness)
Muscle cramps (painful sensations caused by muscle contraction)
Otitis media (inflammation of the middle ear)
Pain
Sluggishness (lacking alertness)
Speech disorder
Thirst

60+:

Fall
Hypoglycaemia (deficiency of glucose in the bloodstream)
Osteonecrosis (death of bone)
Purulent discharge (discharge that contains pus)
Renal failure (kidney dysfunction)
Tooth extraction
Cardiac arrest
Asthenia (weakness)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness

What are the existing conditions these people have? *

Type 2 Diabetes: 9 people, 9.38%
Osteoporosis (bones weak and more likely to break): 5 people, 5.21%

* Approximation only. Some reports may have incomplete information.

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