Gravol and Vitamin e drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Gravol (dimenhydrinate) and Vitamin e (tocopherols and tocotrienols). Common drug interactions include respiratory distress among females and gamma-glutamyltransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Gravol and Vitamin e. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Gravol?

Gravol has active ingredients of dimenhydrinate. It is often used in nausea. eHealthMe is studying from 7,192 Gravol users. Check the latest studies of Gravol.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

24 people who take Gravol and Vitamin e together, and have interactions are studied.

What are the common drug interactions of Gravol and Vitamin E, by gender? *:

female:

Respiratory distress (difficulty in breathing)
Speech disorder
Arrhythmia (irregular heartbeat)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac disorder
Cardiac failure
Confusional state
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Dermatitis allergic (inflammation of the skin due allergic reaction)

male:

Gamma-glutamyltransferase increased
Hepatic failure (liver failure)
Aspartate aminotransferase increased
Blood albumin decreased
Blood alkaline phosphatase increased
Blood calcium decreased
Blood creatinine increased
Blood lactate dehydrogenase increased
Blood potassium increased
Blood pressure systolic increased

What are the common drug interactions of Gravol and Vitamin E, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac failure
Drug intolerance (drug sensitivity)
Dysphagia (a condition in which swallowing is difficult or painful)

30-39:

Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypoaesthesia (reduced sense of touch or sensation)
Limb discomfort (discomfort in leg)
Lymphocyte count decreased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Pneumonia
Pyrexia (fever)
Thyroxine free increased
Tremor (trembling or shaking movements in one or more parts of your body)
Urine abnormality

40-49:

Hepatic failure (liver failure)
Abdominal discomfort
Alanine aminotransferase increased
Ascites (accumulation of fluid in the abdominal cavity)
Gamma-glutamyltransferase increased
Hepatitis fulminant (life-threatening condition defined by significantly impaired liver function)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Death
Drug toxicity
Hepatitis (inflammation of the liver)

50-59:

Abdominal pain
Arthralgia (joint pain)
Chest pain
Confusional state
Constipation
Dermatitis allergic (inflammation of the skin due allergic reaction)
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Fatigue (feeling of tiredness)
Gait disturbance

60+:

Dyspnoea (difficult or laboured respiration)
Fall
Blood alkaline phosphatase increased
Blood calcium decreased
Blood creatinine increased
Blood lactate dehydrogenase increased
Blood potassium increased
Blood pressure systolic increased
Blood sodium decreased
Cardiomegaly (increased size of heart than normal)

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 20.83%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 4 people, 16.67%
Back Pain: 4 people, 16.67%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 3 people, 12.50%
Depression: 3 people, 12.50%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 3 people, 12.50%
Flatulence (flatus expelled through the anus): 3 people, 12.50%
Incision Site Pain: 2 people, 8.33%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 2 people, 8.33%
Fever: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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