Naproxen and Zinacef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Zinacef (cefuroxime sodium). Common drug interactions include renal failure among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Zinacef. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Zinacef?

Zinacef has active ingredients of cefuroxime sodium. eHealthMe is studying from 1,802 Zinacef users. Check the latest studies of Zinacef.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

12 people who take Naproxen and Zinacef together, and have interactions are studied.

What are the common drug interactions of Naproxen and Zinacef, by gender? *:

female:

Renal failure (kidney dysfunction)
Abscess (pus)
Alanine aminotransferase increased
Anaemia (lack of blood)
Anxiety
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood bilirubin increased
Blood creatinine increased
Blood glucose increased

male:

Renal failure (kidney dysfunction)
Anxiety
Multi-organ failure (multisystem organ failure)
Stress
Cardiac disorder
Depression
Organ failure
Acute respiratory distress syndrome
Coma (state of unconsciousness lasting more than six hours)
Deafness unilateral

What are the common drug interactions of Naproxen and Zinacef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dyspnoea (difficult or laboured respiration)
Rash macular (small, flat red spots)
Rash pruritic (redness with itching)

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Death
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Death
Fear
Injury
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

60+:

Renal failure (kidney dysfunction)
Anxiety
Acute respiratory distress syndrome
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Breast pain
Cardiac arrest
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Colitis pseudomembranous (antibiotic-associated diarrhoea)

What are the existing conditions these people have? *

High Blood Pressure: 2 people, 16.67%
Thrombocytopenia (decrease of platelets in blood): 1 person, 8.33%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 8.33%
Oedema (fluid collection in tissue): 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 8.33%
Enterococcal Sepsis: 1 person, 8.33%
Diabetes: 1 person, 8.33%
Cardiac Failure Congestive: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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