Harvoni and Amlodipine besylate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Harvoni (ledipasvir; sofosbuvir) and Amlodipine besylate (amlodipine besylate). Common drug interactions include peripheral swelling among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Harvoni and Amlodipine besylate. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Harvoni?

Harvoni has active ingredients of ledipasvir; sofosbuvir. eHealthMe is studying from 19,858 Harvoni users. Check the latest studies of Harvoni.

What is Amlodipine besylate?

Amlodipine besylate has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 75,293 Amlodipine besylate users. Check the latest studies of Amlodipine besylate.

On Jul, 04, 2026

52 people who take Harvoni and Amlodipine besylate together, and have interactions are studied.

Harvoni and Amlodipine besylate drug interactions.

What are the common drug interactions of Harvoni and Amlodipine Besylate, by gender? *:

female:

Peripheral swelling
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Protein urine present
Quality of life decreased
Restlessness (not able to rest)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urticaria (rash of round, red welts on the skin that itch intensely)
Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Pain

male:

Fatigue (feeling of tiredness)
Angioedema (rapid swelling of the dermis)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arteriovenous fistula
Arteriovenous fistula site infection
Ascites (accumulation of fluid in the abdominal cavity)
Blood calcium decreased
Blood creatinine increased
Blood urine present
Bone density decreased

What are the common drug interactions of Harvoni and Amlodipine Besylate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Rib fracture
Road traffic accident
Skeletal injury (bone and supporting muscle injury)
Upper limb fracture
Visual impairment

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood calcium decreased
Blood urine present
Chronic kidney disease
Emotional distress
Osteoporosis (bones weak and more likely to break)
Pain
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)

60+:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Abdominal distension
Abnormal weight gain
Acute myocardial infarction (acute heart attack)
Agitation (state of anxiety or nervous excitement)
Anxiety
Arteriovenous fistula
Arteriovenous fistula site infection

What are the existing conditions these people have? *

Hepatitis C: 13 people, 25.00%
Multiple Myeloma (cancer of the plasma cells): 5 people, 9.62%
Pain: 4 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.69%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 5.77%
Insomnia (sleeplessness): 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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