Hiprex and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Hiprex (methenamine hippurate) and Methotrexate (methotrexate sodium). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Hiprex and Methotrexate. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Hiprex?

Hiprex has active ingredients of methenamine hippurate. It is often used in urinary tract infection. eHealthMe is studying from 900 Hiprex users. Check the latest studies of Hiprex.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,314 Methotrexate users. Check the latest studies of Methotrexate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

26 people who take Hiprex and Methotrexate together, and have interactions are studied.

Hiprex and Methotrexate drug interactions.

What are the common drug interactions of Hiprex and Methotrexate, by gender? *:

female:

Fatigue (feeling of tiredness)
Chest discomfort
Erythema (redness of the skin)
Herpes zoster
Lower respiratory tract infection
Muscle tightness
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia

male:

n/a

What are the common drug interactions of Hiprex and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dizziness
Malaise (a feeling of general discomfort or uneasiness)
Influenza like illness
Secondary progressive multiple sclerosis (a stage of ms which comes after relapsing remitting ms in many cases)
Balance disorder
Blood pressure increased
Body temperature increased
Chest discomfort
Chest pain
Cough

60+:

Diarrhoea
Breast cancer female
Blood potassium decreased
Blood urea increased
Body temperature increased
Bradycardia (abnormally slow heart action)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Cardiac arrest
Chest pain
Chills (felling of cold)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 19.23%
Osteoporosis (bones weak and more likely to break): 4 people, 15.38%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 2 people, 7.69%
Nausea (feeling of having an urge to vomit): 2 people, 7.69%
Muscle Spasms (muscle contraction): 2 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.69%
Diabetes: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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